{"title":"在培养皿中模拟阿尔茨海默病--剖析人类神经元中的淀粉样蛋白-β代谢过程","authors":"Elizabeth Hill, Thomas J Cunningham","doi":"10.1042/ns20230020","DOIUrl":null,"url":null,"abstract":"This scientific commentary refers to ‘Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition’ by Rowland et al. (https://doi.org/10.1042/NS20230016). Insulin-degrading enzyme (IDE) and neprilysin (NEP) have been proposed as two Aβ-degrading enzymes supported by human genetics and in vivo data. Rowland et al. provide complementary evidence of a key role for IDE in Aβ metabolism in human induced pluripotent stem cell (iPSC)-derived cortical neurons.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Modelling Alzheimer’s disease in a Dish – Dissecting Amyloid-β Metabolism in Human Neurons\",\"authors\":\"Elizabeth Hill, Thomas J Cunningham\",\"doi\":\"10.1042/ns20230020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This scientific commentary refers to ‘Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition’ by Rowland et al. (https://doi.org/10.1042/NS20230016). Insulin-degrading enzyme (IDE) and neprilysin (NEP) have been proposed as two Aβ-degrading enzymes supported by human genetics and in vivo data. Rowland et al. provide complementary evidence of a key role for IDE in Aβ metabolism in human induced pluripotent stem cell (iPSC)-derived cortical neurons.\",\"PeriodicalId\":74287,\"journal\":{\"name\":\"Neuronal signaling\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuronal signaling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1042/ns20230020\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Neuroscience\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuronal signaling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1042/ns20230020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}
Modelling Alzheimer’s disease in a Dish – Dissecting Amyloid-β Metabolism in Human Neurons
This scientific commentary refers to ‘Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition’ by Rowland et al. (https://doi.org/10.1042/NS20230016). Insulin-degrading enzyme (IDE) and neprilysin (NEP) have been proposed as two Aβ-degrading enzymes supported by human genetics and in vivo data. Rowland et al. provide complementary evidence of a key role for IDE in Aβ metabolism in human induced pluripotent stem cell (iPSC)-derived cortical neurons.
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