1-(2,5-二甲氧基-4-硝基苯基)哌啶

IF 0.6 Q4 CHEMISTRY, ORGANIC Molbank Pub Date : 2023-11-27 DOI:10.3390/m1744

T. M. Syeda, Muadh R. Al-Shaidi, Ibtihal Basri, M. Merzouk, F. Aldabbagh

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引用次数: 0

摘要

用哌啶处理从 1,4-二甲氧基苯硝化过程中得到的二硝基异构体非纯化混合物，可分离出新颖但次要的加合物 1-（2,5-二甲氧基-4-硝基苯基）哌啶（2b），产率为 15%。当使用纯化的 1,4-二甲氧基-2,5-二硝基苯（1b）与哌啶和吡咯烷反应时，亲核芳香取代加合物的产率很高，可分别得到产率为 76% 和 82% 的 (2b) 和 1-(2,5-二甲氧基-4-硝基苯基)吡咯烷 (3b)。

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1-(2,5-Dimethoxy-4-nitrophenyl)piperidine

Treatment of the non-purified mixture of dinitro isomers obtained from the nitration of 1,4-dimethoxybenzene with piperidine led to the isolation of novel but minor adduct, 1-(2,5-dimethoxy-4-nitrophenyl)piperidine (2b) in 15% yield. Yields of nucleophilic aromatic substitution adducts are high when using purified 1,4-dimethoxy-2,5-dinitrobenzene (1b) with piperidine and pyrrolidine to give (2b) and 1-(2,5-dimethoxy-4-nitrophenyl)pyrrolidine (3b) in 76% and 82% yield, respectively.

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)