B. Dwiputra, Anwar Santoso, Budhi Setianto Purwowiyoto, B. Radi, B. Pandhita, Serlie Fatrin, A. M. Ambari
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Current Evidence and Future Directions of Omega-3 Supplementation and Cardiovascular Disease Risk
Abstract Omega-3 supplementation has a controversial role in the secondary prevention of cardiovascular diseases. Despite large clinical trials published over the years, the evidence of omega-3 in preventing cardiovascular diseases, especially coronary heart disease, is still inconclusive. However, recent clinical trials using higher dose of omega-3 or highly purified esters of omega-3 shows promising result, with reduction in cardiovascular death and incidence of cardiovascular disease. This review aims to summarize the possible mechanism of omega-3 in preventing cardiovascular disease and future directions of research regarding the benefit of omega-3 in cardiovascular disease.
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