Mohammed Alwan Farhan, Wijdan Amer Ibrahim, W. Ali
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引用次数: 0
摘要
本研究以化合物[1,2-双-(4-氨基-5-巯基-4H-[1,2,4]三唑-3-基)-乙烷-1,2-二醇]为起始原料,合成了不同的席夫碱化合物。酒石酸与硫代酰肼的融合产生了化合物(C1),而希夫碱(C2-C4)则是通过物质(C1)与不同取代的苯甲醛在冰醋酸作为催化剂的存在下缩合而成。使用薄层色谱法(TLC)确认化合物的纯度,并使用光谱法(傅立叶变换红外光谱)和磁核共振光谱法(1H-NMR 和 13C-NMR)推断化合物的结构。采用琼脂井扩散法测试合成化合物对肺炎双球菌和金黄色葡萄球菌的抗菌活性,结果不一致。测试了目标物质在 50 克/毫升和 100 克/毫升浓度下杀死人类乳腺癌的能力。人类肌肉组织 HC 正常细胞系、人类宫颈癌 Hela 细胞系和 HePG2 细胞系。结果表明,这些化学物质对 Hela 细胞系具有潜在的细胞毒性活性,尤其是化合物 (C4),在 100 毫克/毫升的剂量下,其抑制作用在受检物质中最大。
Synthesis, Evaluation of anticancer and antimicrobial activities of some Schiff bases derivatives
In this research, compound [1,2-Bis-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-ethane-1,2-diol] was used as starting material for synthesis different Schiff's Bases compounds. The fusion of tartaric acid with thiocarbohydrazide produce the compound (C1), the Schiff's bases (C2-C4) were created through the condensation of substances (C1) with different substituted benzaldehydes in presence of glacial acetic acid as catalyst. Thin layer chromatography (TLC) was used to confirm the compounds' purity, and spectroscopic methods were used to infer the compounds' structures (FTIR) and magnetic nuclear resonance spectroscopy (1H-NMR and 13C-NMR). The agar well diffusion method was used to test synthesized compounds for their antibacterial activity against K. pneumonia and S. aureus, and the findings were inconsistent. Target substances were tested for their ability to kill human breast cancer at concentrations of 50 and 100 g/mL. Human muscle tissue HC normal cell line, human cervical cancer Hela cell line, and HePG2 cell line. The results showed that the chemicals had potential cytotoxic activity against the Hela cell line, particularly compound (C4), which had the greatest inhibition at doses of 100 mg/mL among the examined substances