血脂与非酒精性脂肪肝之间的相互关系

Livers Pub Date : 2023-11-23 DOI:10.3390/livers3040045
Divyavani Gowda, Chandra Shekar, S. G. B. Gowda, Yifan Chen, Shu-Ping Hui
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引用次数: 0

摘要

非酒精性脂肪肝(NAFLD)是一种复杂的肝脏疾病,可导致非酒精性脂肪性肝炎、肝硬化和肝癌。非酒精性脂肪肝的病理生理学受多个变量的影响,如代谢失调、氧化应激、炎症和遗传易感性。由于非酒精性脂肪肝与肥胖、胰岛素抵抗、2 型糖尿病和其他代谢紊乱有关,因此严重威胁全球健康。近年来,脂质-NAFLD 之间的相互影响引起了人们的广泛关注。通过多种方法,人们发现血脂与非酒精性脂肪肝的发病和发展有关。血脂与非酒精性脂肪肝之间的联系是本综述的主要话题,同时还涉及各种治疗靶点和现有药物。文章总结了肝脏脂质代谢在非酒精性脂肪肝进展过程中的重要性,并介绍了该领域的最新研究成果。
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Crosstalk between Lipids and Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD), a complex liver disorder that can result in non-alcoholic steatohepatitis, cirrhosis, and liver cancer, is the accumulation of fat in the liver seen in people due to metabolic dysfunction. The pathophysiology of NAFLD is influenced by several variables, such as metabolic dysregulation, oxidative stress, inflammation, and genetic susceptibility. This illness seriously threatens global health because of its link to obesity, insulin resistance, type 2 diabetes, and other metabolic disorders. In recent years, lipid–NAFLD crosstalk has drawn a lot of interest. Through numerous methods, lipids have been connected to the onset and advancement of the illness. The connection between lipids and NAFLD is the main topic of the current review, along with the various therapeutic targets and currently available drugs. The importance of hepatic lipid metabolism in the progression of NAFLD is summarized with the latest results in the field.
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