与三阴性乳腺癌肿瘤进展相关的血单核细胞分子图谱

M. Patysheva, A. A. Frolova, O. Bragina, A. A. Fedorov, M. A. Vostrikova, E. Garbukov, P. Iamshchikov, M. Vashisth, N. Cherdyntseva, T. S. Gerashchenko, М.Р. Патышева, А. А. Фролова, О.Д. Брагина, А. А. Федоров, М.С. Вострикова, Е. Ю. Гарбуков, П.С. Ямщиков, М. Вашитш, Н. В. Чердынцева, Т.С. Геращенко, M. A. Vostrikova, Pavel S. Iamshikov
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引用次数: 0

摘要

导言:三阴性乳腺癌是一种侵袭性临床表型,其特点是预后不良。免疫系统在实体瘤的发展、治疗反应和进展中发挥着重要作用。利用高分辨率分子技术寻找与预测疗效和疾病预后相关的免疫相关标记物是一个前景广阔的研究领域,其结果可转化为临床实践。病例描述该病例描述了一名 48 岁女性患者血液单核细胞的分子特征,该患者经组织学证实患有三阴性乳腺癌(雌激素受体-0;孕激素受体-0;Her2/neu-0;gata-3-0;雄激素受体-0;Ki67-70%)。患者对紫杉醇+卡铂 4 个周期的新辅助化疗无反应,随后接受了阿霉素+环磷酰胺 2 个周期的化疗。患者接受了手术治疗。术后 2 个月出现了疾病进展(盆腔骨转移)。文中描述了与新辅助化疗无反应和疾病进展相关的血液淋巴细胞和单核细胞特征。该临床病例表明,外周血单核细胞测序可作为一种方法,用于确定疗效预测标志物,并为三阴性乳腺癌患者开发个性化治疗方案。
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Blood mononuclear cell molecular landscape associated with tumor progression in triple-negative breast cancer
Introduction. triple negative breast cancer is an aggressive clinical phenotype characterized by poor prognosis. immune system plays an important role in the development, treatment response, and progression of solid tumor. The search for immune-related markers associated with the prediction of treatment efficacy and disease prognosis, and based on the use of high-resolution molecular techniques, is a promising area of research, the results of which can be translated into clinical practice. Case description. The molecular profile of blood mononuclear cells in a 48-year-old female patient with histologically proven triple negative breast cancer (estrogen Receptor – 0; progesteron Receptor – 0; Her2/neu – 0; gata-3 – 0, androgen Receptor – 0 and Ki67 – 70 %) was described. The patient did not response to neoadjuvant chemotherapy with 4 cycles of paclitaxel + carboplatin followed by 2 cycles of adriamycin + cyclophosphamide. The patient underwent surgery. disease progression (pelvic bone metastases) occurred 2 months after surgery. The features of blood lymphocytes and monocytes associated with a lack of response to neoadjuvant chemotherapy and disease progression were described.Conclusion. This clinical case demonstrates that sequencing of peripheral blood mononuclear cells can be used as a method for identifying predictive markers of therapy efficacy and developing personalized treatments for patients with triple negative breast cancer.
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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