妊娠糖尿病、糖耐量受损和正常糖耐量的产妇和围产期结果比较研究

Balaji Vijayam, Manoranjani K, Anandhi A, Shanmugam A, T. Balaji, M. Balaji, Seshiah Veerasamy, Vinothapooshan Ganesan
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摘要

妊娠糖尿病(GDM)和糖耐量受损(IGT)是最常见的围产期代谢和内分泌问题,也是全球日益关注的健康问题。这是一个有争议的实体,其政策和程序相互竞争。美国大多数医生采用两步程序,首先在孕 24-28 周进行 50 克非空腹口服葡萄糖挑战测试,然后对筛查结果呈阳性的妇女进行 100 克空腹测试。相反,医生们采用印度妊娠糖尿病研究小组(DIPSI)的技术,只进行 75 克、两小时的空腹口服葡萄糖耐量试验。这项前瞻性观察研究获得了医院机构伦理委员会的批准,于 2020 年 4 月至 2021 年 9 月在印度泰米尔纳德邦钦奈市斯坦利医学院附属医院妇产科进行。患者是根据纳入标准挑选的,该标准要求是无糖尿病的头胎孕妇。此外,还获得了口头和书面同意。DIPSI 进行了筛查。世卫组织的标准已更新为单一血糖值的一步式流程。根据这项研究的结果,GDM 与可能影响母亲和胎儿的有害后果有关。如果能及早发现并及时治疗这种疾病,就能大大减少对母亲和新生儿造成的短期和长期影响。在这项研究中,GDM 和 IGT 母亲的出生体重在 2.5 至 3.5 公斤之间。IGT产妇也应进行随访,即使我们对GDM产妇进行监测,也应在其出生时多加留意。
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A comparison study of maternal and perinatal outcomes with gestational diabetes mellitus, impaired glucose tolerance, and normal glucose tolerance
Gestational diabetes mellitus (GDM) and impaired glucose tolerance (IGT), which are growing health concerns globally, are the most common metabolic and endocrine perinatal issues. It is a contentious entity with competing policies and procedures. Most physicians in the United States employ a two-step procedure, starting with a 50-g non-fasting oral glucose challenge test at 24 to 28 weeks and moving on to a 100-g fasting test for women who receive a positive screening result. Instead, doctors use the Diabetes in Pregnancy Study Group India (DIPSI) technique and conduct just a 75-g, two-hour fasting oral glucose tolerance test. The prospective observational study was approved by the hospital's institutional ethics committee and was conducted from April 2020 to September 2021 at the department of obstetrics and gynecology at Stanley Medical College Hospital in Chennai, Tamil Nadu, India. The patients were chosen in accordance with the inclusion criteria, which called for first-trimester pregnant women without diabetes mellitus. Both oral and written consent were also obtained. DIPSI performed the screening. The WHO standards have been updated to be a one-step process with a single glycemic value. According to the results of this study, GDM is linked to harmful consequences that might affect both the mother and the foetus. The short- and long-term consequences in both the mother and the newborn can be greatly reduced with early detection and timely therapy of this illness. In this study, birth weights ranging from 2.5 to 3.5 kg were the same for GDM and IGT moms. IGT mothers should also be followed up on, and we should be more watchful at birth, even though we monitor GDM mothers.
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