T. N. Zamay, M. Dymova, A. Narodov, A. A. Koshmanova, D. S. Grek, I. Voronkovskii, A. K. Gorbushin, A. Kichkailo, E. Kuligina, V. A. Richter, R. Zukov
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引用次数: 0
摘要
研究目的:评估在人类脑胶质瘤的诊断、治疗和预后中使用蛋白抗体功能类似物--dNa/ RNa适配体的可行性。在scopus、Web of science、pubmed和elibrary中搜索了相关文献资料,包括2000年至2023年的出版物。我们对有关脑胶质母细胞瘤的分类、诊断和治疗的文献进行了分析,并研究了将aptamers(一种基于DNA/RNA寡核苷酸的分子识别元件,能够与给定的分子靶点结合并区分其中的不同功能基团)用于该疾病的体内诊断和治疗的可行性。文献数据表明,DNA/RNA适配体可用于搜索胶质母细胞瘤患者血液中的循环肿瘤细胞,将治疗药物靶向肿瘤并抑制肿瘤生长。脑胶质母细胞瘤是一种异质性肿瘤,由处于不同恶性阶段的细胞组成,因此具有不同的致癌基因。因此,应提出一种多靶点策略来治疗这种疾病,包括联合抑制肿瘤细胞的血管生成、侵袭、转移、增殖和存活。针对参与致癌转化的关键蛋白定制的DNA/RNA适配体可能是实施脑胶质母细胞瘤多靶点疗法的合适候选物。
Aptamers for the diagnosis and treatment of human glial tumors
Purpose of the study: to evaluate the feasibility of using functional analogues of protein antibodies – dNa/ RNa aptamers in diagnostics, treatment and prognosis of human brain glial tumors.Material and Methods. The relevant literature sources were searched in scopus, Web of science, pubmed, elibrary with inclusion of publications from 2000 to 2023. sixty articles are presented in the review.Results. The analysis of the literature devoted to classification, diagnostics and therapy of brain glioblastomas was carried out and the feasibility of using for in vivo diagnostics and therapy of this disease aptamers, which are molecular recognition elements based on DNA/RNA oligonucleotides, capable of binding to the given molecular targets and distinguishing even separate functional groups in them, was studied. A list of aptamers to human glial brain tumors and their molecular targets that can be used for diagnostics and therapy of glioblastoma, including tumor imaging by pet/ct, mRi, plasmon resonance, fluorescence and confocal microscopy, etc., is presented. literature data suggest that DNA/RNA aptamers can be used to search for circulating tumor cells in the blood of glioblastoma patients, to target therapeutic drugs to the tumor and to inhibit tumor growth.Conclusion. Brain glioblastoma is a heterogeneous tumor consisting of cells at different stages of malignancy and, accordingly, with a different set of oncogenes. For this reason, a multitarget strategy that includes combined suppression of angiogenesis, invasion, metastasis, proliferation and survival of tumor cells should be proposed for the therapy of this disease. DNA/RNA aptamers tailored to key proteins involved in oncogenic transformation may be suitable candidates for the implementation of multitarget therapy for brain glioblastoma.
期刊介绍:
The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets