H D Flad, H Loppnow, W Feist, M H Wang, H Brade, S Kusumoto, E T Rietschel, A J Ulmer
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Interleukin 1 and tumor necrosis factor: studies on the induction by lipopolysaccharide partial structures.
Minimal concentration ranges of lipopolysaccharides, natural and synthetic lipid As, and partial structures were established for the induction of release of IL-1 and TNF from human MNC. LPS was more potent than lipid A. Partial structures of lipid A lacking nonhydroxylated fatty acids were inactive, but in combination with LPS or lipid A exhibited time-dependent synergistic or antagonistic effects.
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