皮下巴西双孢子菌病：罕见、诊断不足但可治愈的真菌感染--病例报告

Q4 Medicine Journal of Mycology and Infection Pub Date : 2023-09-30 DOI:10.17966/jmi.2023.28.3.84

Yoana Fransiska Wahyuning Christi, Irmadita Citrashanty, Yuri Widia, Sylvia Anggraeni, L. Astari, Daniel Edbert, A. P. Kawilarang, Evy Ervianti

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引用次数: 0

摘要

巴氏真菌病（Basidiobolomycosis）是一种罕见的深部真菌感染，由巴氏真菌（Basidiobolus ranarum）引起，以出现肿胀的红斑结节性病变为特征。多种唑类药物已被证明可有效治疗该病。在此，我们报告了一例起初被误诊为其他疾病的基霉菌病患者，在服用伊曲康唑后，病情得到缓解。一名 25 岁的男子因右臂、脸部和颈部大面积肿胀就诊 2.5 年。起初，他被诊断为脂肪瘤和肩胛结核；然而，手术后和服用结核药物后，情况均未见好转。组织病理学检查发现了巨细胞、无菌菌丝和 Splendore-Hoeppli 现象。真菌培养证实，分离出的菌株是巴氏菌（Basidiobolus ranarum）。患者口服伊曲康唑 200 毫克，每天两次，经过 25 个月的治疗后，病情得到完全缓解。

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Subcutaneous Basidiobolomycosis: A Rare and Underdiagnosed but Curable Fungal Infection - A Case Report

Basidiobolomycosis is a rare deep fungal infection caused by Basidiobolus ranarum and characterized by the development of swollen erythematous nodular lesions. Several azoles have been shown to be an effective treatment for this condition. Herein, we report a case of basidiobolomycosis that was initially misdiagnosed as a different disease and resolved after itraconazole medication. A 25-year-old man presented with a 2.5-year history of extensive swelling on his right arm, face, and neck. Initially, he was diagnosed with lipoma and scapular tuberculosis; however, no improvements were observed post-surgery and with tuberculosis medication. Histopathological examinations revealed giant cells, aseptate hyphae, and the Splendore-Hoeppli phenomenon. Fungal culture confirmed the isolate to be Basidiobolus ranarum. The patient was given oral itraconazole 200 mg twice daily, and the complete resolution was achieved after 25 months of treatment.

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来源期刊

Journal of Mycology and Infection Medicine-Infectious Diseases

CiteScore

0.20

自引率

0.00%

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期刊介绍： The Journal of mycology and infection (Acronym: JMI, Abbreviation: J Mycol Infect) aims to publish articles of exceptional interests in the field of medical mycology. The journal originally was launched in 1996 as the Korean Journal of Medical Mycology and has reformed into the current state beginning on March of 2018. The contents of the journal should elucidate important microbiological fundamentals and provide qualitative insights to respective clinical aspects. JMI underlines the submission of novel findings and studies in clinical mycology that are enriched by analyses achieved through investigative methods. The journal should be of general interests to the scientific communities at large and should provide medical societies with advanced breadth and depth of mycological expertise. In addition, the journal supplements infectious diseases in adjunct to the field of mycology to address a well-rounded understanding of infectious disorders. The Journal of mycology and infection, which is issued quarterly, in March, June, September and December each year, published in English. The scope of the Journal of mycology and infection includes invited reviews, original articles, case reports, letter to the editor, and images in mycology. The journal is compliant to peer-review/open access and all articles undergo rigorous reviewing processes by our internationally acknowledged team of editorial boards. The articles directed to publication should encompass in-depth materials that employ scholastic values of mycology and various infectious diseases. Articles responding to critical methodology and outcomes which have potential to enhance better understanding of mycology and infectious diseases are also suitable for publication.