{"title":"针对稳定期非节段性白癜风患者的双盲安慰剂对照治疗试验:使用准分子光照射增强的特制还原抗氧化凝胶","authors":"Abdallah Hassan, Shaker Ezzeddin, Emad Elrewiny","doi":"10.21608/ijma.2023.241003.1828","DOIUrl":null,"url":null,"abstract":"Article information Background: Vitiligo is a common skin condition that causes patches of lightening that affect 0.2 to 0.5 percent of the world's population. It is marked by chalky white macules because melanocytes are being selectively lost. Several ideas have been put forward about what causes the disease, such as an autoimmune, genetic, neural, biochemical, melanocyte cell self-destruction, or oxidative stress theory, which means that too much hydrogen peroxide [H2O2] builds up in the top layer of skin. Aim of the Study: We want to find out how well a special gel called \"pseudo catalase\" with reducing ingredients fights the over-oxygenation of skin melanocytes and epidermal cells that is made worse by excimer light exposure in a person with stable non-segmental vitiligo compared to a gel that doesn't do anything different on the same person. Patients and Methods: The study included 31 stable non-segmental vitiligo patients who attended the dermatological outpatients' clinic at Al-Hussein University Hospital in Cairo, Egypt, during the period between September 2021 and August 2022. The study was divided into 2 groups of lesions in the same patient: group A [test gel + excimer light, Narrow Band UVB exposure] and group B [placebo gel + excimer light, Narrow Band UVB exposure]. Results: The following results were recorded for our patients: The mean age was 25.7 ± 9.3 years. There were 18 males [58.1%] and 13 females [41.9%]. 22 patients [71%] were of skin type III and 9 cases [29%] were of skin type IV. The VASI score values detected showed a great difference before and after treatment, as group A was [0.42 ± 0.3] when compared with the VASI score in group B [1.12 ± 0.5]. Conclusion: Excimer-light-enhanced topical antioxidant pseudo-catalase gel is a highly efficient therapy in the treatment of stable non-segmental vitiligo.","PeriodicalId":53130,"journal":{"name":"International Journal of Medical Arts","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Double-Blind Placebo Controlled Therapeutic Trial on Patients with Stable Non-Segmental Vitiligo Using a Specially Formulated Reducing Antioxidant Gel Enhanced by Excimer Light Exposure\",\"authors\":\"Abdallah Hassan, Shaker Ezzeddin, Emad Elrewiny\",\"doi\":\"10.21608/ijma.2023.241003.1828\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Article information Background: Vitiligo is a common skin condition that causes patches of lightening that affect 0.2 to 0.5 percent of the world's population. It is marked by chalky white macules because melanocytes are being selectively lost. Several ideas have been put forward about what causes the disease, such as an autoimmune, genetic, neural, biochemical, melanocyte cell self-destruction, or oxidative stress theory, which means that too much hydrogen peroxide [H2O2] builds up in the top layer of skin. Aim of the Study: We want to find out how well a special gel called \\\"pseudo catalase\\\" with reducing ingredients fights the over-oxygenation of skin melanocytes and epidermal cells that is made worse by excimer light exposure in a person with stable non-segmental vitiligo compared to a gel that doesn't do anything different on the same person. Patients and Methods: The study included 31 stable non-segmental vitiligo patients who attended the dermatological outpatients' clinic at Al-Hussein University Hospital in Cairo, Egypt, during the period between September 2021 and August 2022. The study was divided into 2 groups of lesions in the same patient: group A [test gel + excimer light, Narrow Band UVB exposure] and group B [placebo gel + excimer light, Narrow Band UVB exposure]. Results: The following results were recorded for our patients: The mean age was 25.7 ± 9.3 years. There were 18 males [58.1%] and 13 females [41.9%]. 22 patients [71%] were of skin type III and 9 cases [29%] were of skin type IV. The VASI score values detected showed a great difference before and after treatment, as group A was [0.42 ± 0.3] when compared with the VASI score in group B [1.12 ± 0.5]. Conclusion: Excimer-light-enhanced topical antioxidant pseudo-catalase gel is a highly efficient therapy in the treatment of stable non-segmental vitiligo.\",\"PeriodicalId\":53130,\"journal\":{\"name\":\"International Journal of Medical Arts\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Medical Arts\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/ijma.2023.241003.1828\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Medical Arts","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ijma.2023.241003.1828","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
文章信息 背景:白癜风是一种常见的皮肤病,会导致皮肤变白,全球有 0.2% 至 0.5% 的人患有此病。由于黑色素细胞选择性脱失,白斑呈白垩色。关于这种疾病的病因,人们提出了几种观点,如自身免疫、遗传、神经、生化、黑色素细胞自毁或氧化应激理论,即皮肤表层堆积过多的过氧化氢[H2O2]。研究目的:我们想了解一种含有还原成分的名为 "伪过氧化氢酶 "的特殊凝胶与一种对同一患者没有任何不同作用的凝胶相比,对稳定期非节段性白癜风患者因准分子光照射而加重的皮肤黑色素细胞和表皮细胞过度氧化有多大作用。患者和方法:研究对象包括2021年9月至2022年8月期间在埃及开罗侯赛因大学医院皮肤科门诊就诊的31名稳定期非节段性白癜风患者。研究将同一患者的皮损分为两组:A组[测试凝胶+准分子光,窄带UVB照射]和B组[安慰剂凝胶+准分子光,窄带UVB照射]。结果:患者的记录结果如下:平均年龄为 25.7 ± 9.3 岁。男性 18 名[58.1%],女性 13 名[41.9%]。22 例患者[71%]为 III 型皮肤,9 例患者[29%]为 IV 型皮肤。检测到的 VASI 评分值在治疗前后有很大差异,A 组为 [0.42 ± 0.3],而 B 组的 VASI 评分为 [1.12 ± 0.5]。结论准分子光增强型局部抗氧化剂伪催化酶凝胶是治疗稳定期非节段性白癜风的一种高效疗法。
A Double-Blind Placebo Controlled Therapeutic Trial on Patients with Stable Non-Segmental Vitiligo Using a Specially Formulated Reducing Antioxidant Gel Enhanced by Excimer Light Exposure
Article information Background: Vitiligo is a common skin condition that causes patches of lightening that affect 0.2 to 0.5 percent of the world's population. It is marked by chalky white macules because melanocytes are being selectively lost. Several ideas have been put forward about what causes the disease, such as an autoimmune, genetic, neural, biochemical, melanocyte cell self-destruction, or oxidative stress theory, which means that too much hydrogen peroxide [H2O2] builds up in the top layer of skin. Aim of the Study: We want to find out how well a special gel called "pseudo catalase" with reducing ingredients fights the over-oxygenation of skin melanocytes and epidermal cells that is made worse by excimer light exposure in a person with stable non-segmental vitiligo compared to a gel that doesn't do anything different on the same person. Patients and Methods: The study included 31 stable non-segmental vitiligo patients who attended the dermatological outpatients' clinic at Al-Hussein University Hospital in Cairo, Egypt, during the period between September 2021 and August 2022. The study was divided into 2 groups of lesions in the same patient: group A [test gel + excimer light, Narrow Band UVB exposure] and group B [placebo gel + excimer light, Narrow Band UVB exposure]. Results: The following results were recorded for our patients: The mean age was 25.7 ± 9.3 years. There were 18 males [58.1%] and 13 females [41.9%]. 22 patients [71%] were of skin type III and 9 cases [29%] were of skin type IV. The VASI score values detected showed a great difference before and after treatment, as group A was [0.42 ± 0.3] when compared with the VASI score in group B [1.12 ± 0.5]. Conclusion: Excimer-light-enhanced topical antioxidant pseudo-catalase gel is a highly efficient therapy in the treatment of stable non-segmental vitiligo.