Ibrahim Abd-Elfattah, Mohamed Abdelkhalek, A. El-Shahat, Ahmed Abozeid
{"title":"自发性细菌性腹膜炎腹水内切酶的诊断价值","authors":"Ibrahim Abd-Elfattah, Mohamed Abdelkhalek, A. El-Shahat, Ahmed Abozeid","doi":"10.21608/ijma.2023.234271.1802","DOIUrl":null,"url":null,"abstract":"Article information Background: Endocan is a potential marker of many immune-inflammatory conditions. It may be linked to liver cirrhosis. Increased endocan levels is linked to liver diseases [e.g., chronic hepatitis] which could be developed to liver decompensation and may be elevated in ascetic fluid. Aim of the work: The current work aimed to evaluate the role of ascetic endocan in the diagnosis of Spontaneous Bacterial Peritonitis [SBP] among patients with decompensated cirrhosis. Patients and Methods: In this cross-sectional study, 100 patients with cirrhotic ascites were selected from patients who were admitted to Nasser institute and Al-Azhar University Hospitals during the period from April 2022 to April 2023. All patients were assessed on a clinical basis, and laboratory investigations were performed. The ascetic levels of endocan were measured and compared between groups. Results: Both groups were comparable regarding patient demographics. All patients in non-SBP had negative culture, while 12 patients in SBP group had positive results [10 of E-Coli, one Klebsiella and one Streptococcus viridans]. The major cause of cirrhosis in both groups was the HCV [76% of SBP compared to 80% of the non-SBP group]. The endocan levels showed a significant increase in the SBP than the non-SBP groups [5.20±1.80 vs 2.96±1.80 ng/ml]. Endocan significantly and positively correlated with each of TLC, AST, ALT, creatinine, albumin, bilirubin, INR, CRP, HBsAg and HCV antibodies. The hazardous ratio [HR] for endocan was 1.644 [95% CI: 1.011 – 2.707]. The endocan is also predictive of SBP development with an HR 1.673 [95% CI:1.031 – 2.806]. Conclusion: Ascetic Endocan is increased in ascitic fluid and represents an independent risk factor for SBP, with a significant diagnostic value in patients with decompensated cirrhosis.","PeriodicalId":53130,"journal":{"name":"International Journal of Medical Arts","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic Value of Ascitic Endocan in Spontaneous Bacterial Peritonitis\",\"authors\":\"Ibrahim Abd-Elfattah, Mohamed Abdelkhalek, A. El-Shahat, Ahmed Abozeid\",\"doi\":\"10.21608/ijma.2023.234271.1802\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Article information Background: Endocan is a potential marker of many immune-inflammatory conditions. It may be linked to liver cirrhosis. Increased endocan levels is linked to liver diseases [e.g., chronic hepatitis] which could be developed to liver decompensation and may be elevated in ascetic fluid. Aim of the work: The current work aimed to evaluate the role of ascetic endocan in the diagnosis of Spontaneous Bacterial Peritonitis [SBP] among patients with decompensated cirrhosis. Patients and Methods: In this cross-sectional study, 100 patients with cirrhotic ascites were selected from patients who were admitted to Nasser institute and Al-Azhar University Hospitals during the period from April 2022 to April 2023. All patients were assessed on a clinical basis, and laboratory investigations were performed. The ascetic levels of endocan were measured and compared between groups. Results: Both groups were comparable regarding patient demographics. All patients in non-SBP had negative culture, while 12 patients in SBP group had positive results [10 of E-Coli, one Klebsiella and one Streptococcus viridans]. The major cause of cirrhosis in both groups was the HCV [76% of SBP compared to 80% of the non-SBP group]. The endocan levels showed a significant increase in the SBP than the non-SBP groups [5.20±1.80 vs 2.96±1.80 ng/ml]. Endocan significantly and positively correlated with each of TLC, AST, ALT, creatinine, albumin, bilirubin, INR, CRP, HBsAg and HCV antibodies. The hazardous ratio [HR] for endocan was 1.644 [95% CI: 1.011 – 2.707]. The endocan is also predictive of SBP development with an HR 1.673 [95% CI:1.031 – 2.806]. Conclusion: Ascetic Endocan is increased in ascitic fluid and represents an independent risk factor for SBP, with a significant diagnostic value in patients with decompensated cirrhosis.\",\"PeriodicalId\":53130,\"journal\":{\"name\":\"International Journal of Medical Arts\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Medical Arts\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/ijma.2023.234271.1802\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Medical Arts","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ijma.2023.234271.1802","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Diagnostic Value of Ascitic Endocan in Spontaneous Bacterial Peritonitis
Article information Background: Endocan is a potential marker of many immune-inflammatory conditions. It may be linked to liver cirrhosis. Increased endocan levels is linked to liver diseases [e.g., chronic hepatitis] which could be developed to liver decompensation and may be elevated in ascetic fluid. Aim of the work: The current work aimed to evaluate the role of ascetic endocan in the diagnosis of Spontaneous Bacterial Peritonitis [SBP] among patients with decompensated cirrhosis. Patients and Methods: In this cross-sectional study, 100 patients with cirrhotic ascites were selected from patients who were admitted to Nasser institute and Al-Azhar University Hospitals during the period from April 2022 to April 2023. All patients were assessed on a clinical basis, and laboratory investigations were performed. The ascetic levels of endocan were measured and compared between groups. Results: Both groups were comparable regarding patient demographics. All patients in non-SBP had negative culture, while 12 patients in SBP group had positive results [10 of E-Coli, one Klebsiella and one Streptococcus viridans]. The major cause of cirrhosis in both groups was the HCV [76% of SBP compared to 80% of the non-SBP group]. The endocan levels showed a significant increase in the SBP than the non-SBP groups [5.20±1.80 vs 2.96±1.80 ng/ml]. Endocan significantly and positively correlated with each of TLC, AST, ALT, creatinine, albumin, bilirubin, INR, CRP, HBsAg and HCV antibodies. The hazardous ratio [HR] for endocan was 1.644 [95% CI: 1.011 – 2.707]. The endocan is also predictive of SBP development with an HR 1.673 [95% CI:1.031 – 2.806]. Conclusion: Ascetic Endocan is increased in ascitic fluid and represents an independent risk factor for SBP, with a significant diagnostic value in patients with decompensated cirrhosis.