P. Trivedi, Dharmesh M. Patel, M. Kazi, Priya K. Varma, Archana B Patel
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引用次数: 0
摘要
在进行核型分析时，采用了GTG条带分析。在 FISH 技术中使用了病灶特异性识别器 RUNX1T1/RUNX1 探针。21 三体综合征在刺激性和非刺激性血液培养以及 FISH 技术中均得到证实。所有患者在接受标准诱导治疗后都获得了较好的生存率。本研究强调对所有DS患者进行筛查和随访研究，以了解AMKL的进展情况，从而调整治疗方案。
Pediatric Acute Megakaryoblast Leukemia & Down Syndrome -An Experience of A Single Institute
metaphases achieved and GTG banding was carried out for karyotype analysis. In FISH technique Locus specific Identifier RUNX1T1/RUNX1 probe was used. Trisomy 21 was confirmed in stimulated and unstimulated blood culture and by FISH technique. All patients have better survival with standard induction therapy. The present study highlights the screening of all DS patients and their follow up study to understand the progression to AMKL for tailoring therapy regimen.
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