What to do when h, k and l do not describe all the reflections in the diffraction?

Here I will present a recently determined crystal structure of ipragliflozin L - proline, a pharmaceutical drug used for the treatment of type 2 diabetes. Due to the small crystal size, MicroED was used to determine this structure. Initial phasing was carried out in the orthorhombic space group P 212121, but refinement in this space group proved to be challenging. Subsequent reduction in symmetry to P 21 produced a structure that could be refined