速溶片剂概述

Chavan Achal, Bharatee Chaudhary, V. Redasani, P. Bhagat, R. Mahadik
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引用次数: 0

摘要

速溶片剂是一种广受欢迎的剂型,尤其适用于肌肉和神经系统发育不全的儿童患者,以及患有帕金森氏症或手部震颤的老年患者。目前,胶囊和片剂等固体剂型面临吞咽困难(吞咽困难)等问题,导致许多患者不遵医嘱,使治疗无效。口服剂型和口服途径是各种药物的首选给药途径,但也有其局限性,如首过性代谢、精神病患者、卧床不起和不合作的患者。速溶片剂可在唾液中快速崩解或溶解,无需加水。速溶片剂在几秒钟内(小于 60 秒)就能在唾液中快速溶解,是真正的速溶片剂。尽管口服给药系统存在各种缺点,但它仍然是首选的给药途径。目前已开发出多种传统或专利技术,如喷雾干燥、棉花糖工艺、升华、熔融造粒、直接压缩冷冻干燥/冻干、相变工艺、大规模挤压等,用于制造快速溶解片剂。
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On Overview of Fast dissolving tablet
Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for paediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route is the most preferred route of administration for various drugs have limitations like first-pass metabolism, psychiatric patients, bedridden and uncooperative patients. FDTs are disintegrating or dissolve quickly in the saliva without a need of water. Fast dissolving tablets are designed to dissolve in saliva remarkably faster, within a few seconds (less than 60 seconds), and those are real fast-dissolving tablets. The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery in spite of various disadvantages. There are several technologies that are conventional or patented based on spray drying, cotton candy process, sublimation, melt granulation, direct compression freezes drying/lyophilization, phase transition process, mass extrusion, etc. have been developed for manufacturing of FDTs
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