Muzammil Muzaffar, Arifa Hassan Sheikh, Mohd Rafi Reshi
{"title":"姜黄素对 LPS 诱导的实验性大鼠子痫前期的生化指标和组织病理学检查的影响","authors":"Muzammil Muzaffar, Arifa Hassan Sheikh, Mohd Rafi Reshi","doi":"10.22270/ajprd.v11i3.1230","DOIUrl":null,"url":null,"abstract":"Objective: The objective of the present study was to evaluate the effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats. Materials and Methods: Biochemical examination was done by manual method of kit.Histopathology was done bypathologist. Results: In the LPS treated group, significant increase in SGPT, Albumin, creatinine and CK-BT levels as compared to pregnant control. Also degenerative changes were seen in kidney and liver tissues.Treatment with curcumin (0.36mg/kg)had significant improvement against LPS induced pre-eclampsiachanges in the biochemical markers markers as well as histopathlogical examination. The curcumintreatment ameliorates effect that is induced by LPS. Conclusion: The present study concludes that curcumincan be the treatment of pre-eclamsia as it produced significant effect in biochemical examination as well as decreased the degenerative effect in histopathology examination of kidney and liver.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"13 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats\",\"authors\":\"Muzammil Muzaffar, Arifa Hassan Sheikh, Mohd Rafi Reshi\",\"doi\":\"10.22270/ajprd.v11i3.1230\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: The objective of the present study was to evaluate the effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats. Materials and Methods: Biochemical examination was done by manual method of kit.Histopathology was done bypathologist. Results: In the LPS treated group, significant increase in SGPT, Albumin, creatinine and CK-BT levels as compared to pregnant control. Also degenerative changes were seen in kidney and liver tissues.Treatment with curcumin (0.36mg/kg)had significant improvement against LPS induced pre-eclampsiachanges in the biochemical markers markers as well as histopathlogical examination. The curcumintreatment ameliorates effect that is induced by LPS. Conclusion: The present study concludes that curcumincan be the treatment of pre-eclamsia as it produced significant effect in biochemical examination as well as decreased the degenerative effect in histopathology examination of kidney and liver.\",\"PeriodicalId\":8526,\"journal\":{\"name\":\"Asian Journal of Pharmaceutical Research and Development\",\"volume\":\"13 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Pharmaceutical Research and Development\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22270/ajprd.v11i3.1230\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Pharmaceutical Research and Development","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22270/ajprd.v11i3.1230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats
Objective: The objective of the present study was to evaluate the effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats. Materials and Methods: Biochemical examination was done by manual method of kit.Histopathology was done bypathologist. Results: In the LPS treated group, significant increase in SGPT, Albumin, creatinine and CK-BT levels as compared to pregnant control. Also degenerative changes were seen in kidney and liver tissues.Treatment with curcumin (0.36mg/kg)had significant improvement against LPS induced pre-eclampsiachanges in the biochemical markers markers as well as histopathlogical examination. The curcumintreatment ameliorates effect that is induced by LPS. Conclusion: The present study concludes that curcumincan be the treatment of pre-eclamsia as it produced significant effect in biochemical examination as well as decreased the degenerative effect in histopathology examination of kidney and liver.
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