哺乳动物细胞的神经元和肌肉分化伴随着 PHF10 同工酶表达的变化

IF 0.8 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Doklady Biochemistry and Biophysics Pub Date : 2024-01-08 DOI:10.1134/S1607672923700643
D. O. Bayramova, A. M. Azieva, A. V. Feoktistov,  S. G. Georgieva, N. V. Soshnikova
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引用次数: 0

摘要

SWI/SNF 家族的 PBAF 染色质重塑复合体在组织分化和生物体发育过程中的基因表达调控中发挥着关键作用。PBAF 复合物的亚基具有负责与 N 端组蛋白序列结合的结构域。它决定了复合体与染色质结合的特异性。PHF10 是 PBAF 复合物的一个特定亚基,含有 DPF 结构域,这是一个独特的染色质相互作用结构域。脊椎动物细胞中也存在缺乏 DPF 结构域的 PHF10 异构体。这项研究表明,在人类和小鼠细胞的神经元和肌肉分化过程中,PHF10 同工型的表达发生了变化:没有 DPF 的同工型取代了有 DPF 的同工型。PBAF复合体中PHF10异构体的替代可能会影响其在分化细胞中调控基因的选择性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression

The PBAF chromatin remodeling complex of the SWI/SNF family plays a critical role in the regulation of gene expression during tissue differentiation and organism development. The subunits of the PBAF complex have domains responsible for binding to N-terminal histone sequences. It determines the specificity of binding of the complex to chromatin. PHF10, a specific subunit of the PBAF complex, contains a DPF domain, which is a unique chromatin interaction domain. A PHF10 isoform that lacks the DPF domain is also present in vertebrate cells. This work shows that during neuronal and muscle differentiation of human and mouse cells, the expression of PHF10 isoforms changes: the form that does not have DPF replaces the form in which it is present. Replacement of PHF10 isoforms in the PBAF complex may affect its selectivity in the regulation of genes in differentiating cells.

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来源期刊
Doklady Biochemistry and Biophysics
Doklady Biochemistry and Biophysics 生物-生化与分子生物学
CiteScore
1.60
自引率
12.50%
发文量
68
审稿时长
6-12 weeks
期刊介绍: Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.
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