饮食中添加迷迭香(Rosmarinus officinalis L.)叶粉对链脲佐菌素诱导的糖尿病雄性 Wistar 大鼠具有抗糖尿病作用

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Diabetology Pub Date : 2024-01-04 DOI:10.3390/diabetology5010002
Zelipha N. Kabubii, J. Mbaria, P. M. Mathiu, John M. Wanjohi, Evans N. Nyaboga
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引用次数: 0

摘要

糖尿病是一种代谢紊乱疾病,对全球健康造成沉重负担,并导致高死亡率和高发病率。药用草本植物为治疗糖尿病提供了一种替代传统疗法的可行方法。迷迭香(Rosmarinus officinalis L.)是一种传统药草,一直被用于治疗多种疾病。因此,本研究调查了补充迷迭香叶粉的膳食对链脲佐菌素诱导的糖尿病 Wistar 大鼠的抗糖尿病特性。首先,测定了 R. officinalis 水提取物的植物化学成分和 2,2-二苯基-1-苦基肼(DPPH)自由基清除活性。以链脲菌素诱导的雄性 Wistar 大鼠为研究对象,在其饮食中分别添加 3%、6% 和 12% 的 R. officinalis 叶粉(ROP),连续喂养 6 周。按照标准程序对大鼠的进食量、体重、相对器官重量、血糖、血脂、肌酐、胆红素、丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)进行了测定。结果表明,ROP 水提取物含有大量酚类、黄酮类和单宁酸,具有体外 DPPH 自由基清除活性。根据体内研究,ROP 可降低链脲佐菌素诱导的糖尿病动物的血糖水平(p < 0.05)。与糖尿病对照组相比,糖尿病大鼠膳食中补充 ROP 能显著降低 ALT、AST、胆红素、肌酐、总甘油三酯(TG)、总胆固醇(TC)和低密度脂蛋白(LDL)水平(p < 0.05),同时增加高密度脂蛋白(HDLs)。我们的研究结果表明,补充茜草叶粉的膳食具有抗糖尿病的潜力,并能改善健康状况,动物模型中血脂和肝脏酶谱的改善就证明了这一点。
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Diet Supplementation with Rosemary (Rosmarinus officinalis L.) Leaf Powder Exhibits an Antidiabetic Property in Streptozotocin-Induced Diabetic Male Wistar Rats
Diabetes mellitus is a metabolic disorder that has a high global health burden and causes high mortality and morbidity in humans. Medicinal herbs and plants offer a promising alternative to conventional therapies for the management of diabetes. Rosemary (Rosmarinus officinalis L.) is a traditional medicinal herb that has been used for the management of several diseases. Therefore, the present study investigates the antidiabetic properties of diets supplemented with R. officinalis leaf powder on streptozotocin-induced diabetic Wistar rats. First, the phytochemicals and 2,2-dephenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity of aqueous R. officinalis leaf extract were determined. Streptozotocin-induced diabetic male Wistar rats were fed a diet supplemented with R. officinalis leaf powder (ROP) at 3%, 6%, and 12%, respectively, for 6 weeks. Investigations of food intake, body weight, rat relative organ weights, blood glucose, lipid profiles, creatinine, bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were estimated according to standard procedures. The results show that ROP aqueous extract contains significant amounts of phenolics, flavonoids, and tannins, which exhibit in vitro DPPH free-radical scavenging activity. Based on an in vivo study, ROP reduced blood glucose levels in streptozotocin-induced diabetic animals (p < 0.05). Dietary supplementation with ROP in diabetic rats significantly (p < 0.05) lowered ALT, AST, bilirubin, creatinine, total triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels while increasing high-density lipoproteins (HDLs) when compared with the diabetic control group. Our findings demonstrate that a diet supplemented with R. officinalis leaf powder exhibits an antidiabetic potential with improved health outcomes, as demonstrated by the improved lipid and liver profile enzymes in our animal model.
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