脑膜瘤的分子遗传学特征对采用联合模式治疗的临床过程和复发的影响

G. Sergeev, A. S. Gaytan, M. A. Travin, A. B. Ponomarev, M. A. Afonina, I. A. Savitskaya, F. Yakhya, A. Krivoshapkin
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引用次数: 0

摘要

简介脑膜瘤是最常见的中枢神经系统肿瘤之一,占所有原发性脑肿瘤的 39.7%。该肿瘤起源于蛛网膜脑膜上皮细胞,组织学类型多种多样,可分为 15 个亚型。脑膜瘤的组织学分类使我们能够预测脑膜瘤的行为和疾病复发的风险,并确定治疗策略。然而,组织学亚组患者的临床结果往往与恶性肿瘤的组织学分级不一致。因此,需要一种更可靠的方法,既能确定肿瘤的组织学亚型,又能预测疾病的临床过程,并有可能进行有针对性的治疗。本研究的目的是总结肿瘤基因组和蛋白质组分析结果对癌变影响的现有数据,以及突变变化与非侵入性诊断、治疗和疾病过程之间的关系。在 PubMed 和 Elibrary 系统中进行文献检索,主要包括 2010 年至 2023 年期间的出版物,通过关键词 "脑膜瘤的基因分析 "和同义词识别文章。共找到 550 篇文章,其中 55 篇用于撰写文献综述。对脑膜瘤分子遗传特征的研究将改进分类,并建立与核磁共振成像数据、病程和预后的相关性。
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Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment
Introduction. Meningioma is one of the most common central nervous system tumors, accounting for 39.7 % of all primary brain tumors. The tumor originates from arachnoid meningothelial cells and is characterized by a wide range of histological types classified into 15 subtypes. The histological classification of meningiomas allows us to predict meningioma behavior and the risk of disease recurrence, as well as to define treatment strategies. However, clinical outcomes in histological subgroups of patients are often inconsistent with the histological grade of malignancy. Thus, a more reliable method is needed both to determine the histological subtype of the tumor and to predict the clinical course of the disease with the potential for targeted treatment.The purpose of the study was to summarize the available data on the effect of results of the genomic and proteomic tumor analysis on carcinogenesis with the relationship between the mutational changes and noninvasive diagnosis, treatment and the course of the disease.Material and Methods. Literature search was carried out in the PubMed, Elibrary system, publications were included mainly from 2010 to 2023. with the identification of articles by the keyword “genetic analysis of meningiomas” and synonyms. 550 articles were found, of which 55 were used to write a literature review.Conclusion. The study of the molecular genetic profile of meningiomas will improve the classification and establish a correlation with MRI data, the course of the disease and prognosis.
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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