生长激素、胰岛素样生长因子-1 和胰岛素之间迷人的相互作用。

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrinology and Metabolism Pub Date : 2024-02-01 Epub Date: 2024-01-09 DOI:10.3803/EnM.2024.101

Eline C Nijenhuis-Noort, Kirsten A Berk, Sebastian J C M M Neggers, Aart J van der Lely

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引用次数: 0

摘要

本综述旨在为读者提供有关几种（病理）生理状况的实用概览，在这些状况中，生长激素（GH）、胰岛素样生长因子-1（IGF-1）和胰岛素之间的相互作用知识非常重要。这可能有助于主治医生做出正确的决定，如何干预和改善新陈代谢以造福患者，并了解新陈代谢在具体病例中的反应原因和方式。我们将以 1 型和 2 型糖尿病、肝硬化和肢端肥大症为例，具体讨论 GH、IGF-1 和胰岛素之间的相互作用，因为这些疾病确实需要这方面的知识。

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The Fascinating Interplay between Growth Hormone, Insulin-Like Growth Factor-1, and Insulin.

This review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important. This might help treating physicians in making the right decisions on how to intervene and improve metabolism for the benefit of patients, and to understand why and how metabolism responds in their specific cases. We will specifically address the interplay between GH, IGF-1, and insulin in type 1 and 2 diabetes mellitus, liver cirrhosis, and acromegaly as examples in which this knowledge is truly necessary.

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来源期刊

Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.60

自引率

5.90%

发文量

145

审稿时长

24 weeks

期刊介绍： The aim of this journal is to set high standards of medical care by providing a forum for discussion for basic, clinical, and translational researchers and clinicians on new findings in the fields of endocrinology and metabolism. Endocrinology and Metabolism reports new findings and developments in all aspects of endocrinology and metabolism. The topics covered by this journal include bone and mineral metabolism, cytokines, developmental endocrinology, diagnostic endocrinology, endocrine research, dyslipidemia, endocrine regulation, genetic endocrinology, growth factors, hormone receptors, hormone action and regulation, management of endocrine diseases, clinical trials, epidemiology, molecular endocrinology, neuroendocrinology, neuropeptides, neurotransmitters, obesity, pediatric endocrinology, reproductive endocrinology, signal transduction, the anatomy and physiology of endocrine organs (i.e., the pituitary, thyroid, parathyroid, and adrenal glands, and the gonads), and endocrine diseases (diabetes, nutrition, osteoporosis, etc.).