胰岛素瘤相关蛋白 1 在活检标本小细胞肺癌病理诊断中的意义》（The Significance of Insulinoma-Associated Protein 1 in the Pathological Diagnosis of Small-Cell Lung Cancer in Biopsy Specimens.
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引用次数: 0
摘要
目的我们的目的是研究胰岛素瘤相关蛋白 1（INSM1）免疫组化抗体在 SCLC 活检标本中的临床病理诊断价值。方法选取2022年1月至2023年6月在唐山公仁医院病理科确诊的SCLC活检标本。检测 INSM1 的表达，并与传统神经内分泌标志物突触素（SYP）、嗜铬粒蛋白 A（CHGA）和 CD56 的表达敏感性和特异性进行比较。结果：INSM1表达的敏感性明显高于CHGA（95% vs 50%，P = .000），但INSM1、SYP、CHGA和CD56表达的特异性差异无统计学意义（分别为100% vs 94% vs 98% vs 92%，P = .241、1.000、.126）。结论INSM1 抗体在 SCLC 的表达中显示出较高的灵敏度和特异性，是活检标本临床病理诊断 SCLC 的可靠免疫组化标记物。
The Significance of Insulinoma-Associated Protein 1 in the Pathological Diagnosis of Small-Cell Lung Cancer in Biopsy Specimens.
Objective: Our purpose was to investigate the clinicopathological diagnostic value of immunohistochemical antibody for insulinoma-associated protein 1 (INSM1) in biopsy specimens of SCLC. Methods: Biopsy specimens of SCLC diagnosed at the pathology department of Tangshan Gongren Hospital from January 2022 to June 2023 were selected. INSM1 expression was detected and compared with conventional neuroendocrine markers synaptophysin (SYP), chromogranin A (CHGA), and CD56 regarding expression sensitivity and specificity. Results: The sensitivity of INSM1 expression was significantly higher than that of CHGA (95% vs 50%, P = .000), but there was no statistically significant difference in the specificity of INSM1, SYP, CHGA, and CD56 expression (100% vs 94% vs 98% vs 92%, respectively, P = .241, 1.000, .126). Conclusions: INSM1 antibody shows high sensitivity and specificity in the expression of SCLC and serves as a reliable immunohistochemical marker in the clinicopathological diagnosis of SCLC in biopsy specimens.
期刊介绍：
International Journal of Surgical Pathology (IJSP) is a peer-reviewed journal published eight times a year, which offers original research and observations covering all major organ systems, timely reviews of new techniques and procedures, discussions of controversies in surgical pathology, case reports, and images in pathology. This journal is a member of the Committee on Publication Ethics (COPE).
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