Lydia Pieters , Tessa Blanken , Kirsten van Lunteren , Peter van Harten , Jeroen Deenik
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引用次数: 0
摘要
背景/目的生活方式干预对严重精神疾病（SMI）患者身心健康的影响很有希望，但其潜在机制仍未解决。本研究旨在考察生活方式干预后健康相关结果的变化，并区分直接和间接影响。方法我们对为期 18 个月的住院重症精神病患者多学科生活方式强化治疗（MULTI）研究中的 106 名受试者（62% 为男性，平均年龄=54.7（SD=10.结果MULTI直接关系到阴性症状和精神药物用量的减少，以及身体活动和社会心理功能的改善，这表明MULTI与不同结果领域之间存在独特而直接的联系。其次，我们还发现了同一领域内（如代谢健康）和不同领域间（如代谢健康和社会功能）的结果之间存在关联，这表明 MULTI 具有潜在的间接效应。这些见解有助于为重症精神病患者制定有效的治疗策略。
A Network Model of Health-Related Changes after a Lifestyle-Enhancing Treatment in Patients with Severe Mental Illness: the MULTI Study VI
Background/Objective
The effects of lifestyle interventions on physical and mental health in people with severe mental illness (SMI) are promising, but its underlying mechanisms remain unsolved. This study aims to examine changes in health-related outcomes after a lifestyle intervention, distinguishing between direct and indirect effects.
Method
We applied network intervention analysis on data from the 18-month cohort Multidisciplinary Lifestyle enhancing Treatment for Inpatients with SMI (MULTI) study in 106 subjects (62% male, mean age=54.7 (SD=10.8)) that evaluated changes in actigraphy-measured physical activity, metabolic health, psychopathology, psychosocial functioning, quality of life and medication use after MULTI (n=65) compared to treatment as usual (n=41).
Results
MULTI is directly connected to decreased negative symptoms and psychotropic medication dosage, and improved physical activity and psychosocial functioning, suggesting a unique and direct association between MULTI and the different outcome domains. Secondly, we identified associations between outcomes within the same domain (e.g., metabolic health) and between the domains (e.g., metabolic health and social functioning), suggesting potential indirect effects of MULTI.
Conclusions
This novel network approach shows that MULTI has direct and indirect associations with various health-related outcomes. These insights contribute to the development of effective treatment strategies in people with severe mental illness.
期刊介绍：
The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.
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