幽门螺杆菌根除疗法前后泰国成人当前感染标记物血清检验的诊断有效性

IF 2.5 Q3 ONCOLOGY Journal of Cancer Prevention Pub Date : 2023-12-30 DOI:10.15430/JCP.2023.28.4.194
Setthachai Piwchan, Kittipoom Tossapornpong, Suppana Chuensakul, Ekawee Sripariwuth
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引用次数: 0

摘要

幽门螺杆菌感染对健康构成重大威胁,例如胃腺癌,因此需要在初级保健中进行准确诊断和有效治疗。本研究评估了血清学当前感染标志物(CIM)检测在确定当前幽门螺杆菌感染方面的诊断效果。研究收集了 159 名接受胃镜检查者的 CIM 检测样本,幽门螺杆菌阳性的门诊患者根据组织学或快速尿素酶检测结果接受了三联疗法。治疗后,45 名患者接受了 13C- 尿素呼气测试和 CIM 测试,以评估根除情况。在根除前,CIM 测试的灵敏度为 89.6%,特异性为 95.7%,阳性预测值为 93.8%,阴性预测值为 92.6%,准确率为 93.1%。停药后,以 13C- 尿素呼气测试为参考标准,CIM 测试的灵敏度、特异性、阳性预测值、阴性预测值和准确性分别为 71.4%、92.1%、62.5%、94.6% 和 88.9%。CIM 测试的诊断性能值得称赞,强调了其在消除前和消除后情况下的有效性。值得注意的是,CIM 检验的准确性、无创伤性、用户友好性和成本效益都使其成为基层医疗机构检测幽门螺杆菌感染的首选诊断工具。
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Diagnostic Validity of a Serological Test with the Current Infection Marker in Thai Adults before and after Helicobacter pylori Eradication Therapy.

Helicobacter pylori infection poses significant health risks, such as gastric adenocarcinoma, necessitating accurate diagnosis and effective treatment in primary care. This study evaluated the diagnostic efficacy of the serological current infection marker (CIM) test in identifying current H. pylori infection. The CIM test samples from 159 participants undergoing gastroscopy were collected, and H. pylori-positive outpatients received triple therapy based on histology or rapid urease test results. Following treatment, 45 patients underwent a 13C-urea breath test and the CIM test for eradication assessment. For pre-eradication, the CIM test demonstrated 89.6% sensitivity, 95.7% specificity, 93.8% positive predictive value, 92.6% negative predictive value, and 93.1% accuracy. Following post-eradication, the CIM test exhibited sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 71.4%, 92.1%, 62.5%, 94.6%, and 88.9%, respectively, using the 13C-urea breath test as the reference standard. The CIM test showcased commendable diagnostic performance, emphasizing its efficacy in both pre- and post-eradication scenarios. Notably, the accuracy, non-invasiveness, user-friendliness, and cost-effectiveness of the CIM test advocate for its recommendation as a preferred diagnostic tool in primary care settings for H. pylori infection detection.

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