多发性骨髓瘤的分子发病机制:临床意义。

IF 2.5 3区 医学 Q2 HEMATOLOGY Hematology-Oncology Clinics of North America Pub Date : 2024-01-09 DOI:10.1016/j.hoc.2023.12.010
Francesco Maura MD , Peter Leif Bergsagel MD
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引用次数: 0

摘要

多发性骨髓瘤是一种恶性肿瘤,由骨髓定位、同型切换的浆细胞引起,浆细胞分泌单克隆免疫球蛋白,导致高钙血症、贫血、肾功能衰竭和溶解性骨病。在这种疾病发生之前,往往有一种相对稳定的单克隆丙种球蛋白病,其临床和恶性特征并不明显,而且往往持续数十年之久。这两种疾病的特征都是存在免疫球蛋白重型基因易位类型,这些易位会使 11q13 (CCND1)、6p21 (CCND3) 或 12q11 (CCND2) 上的细胞周期蛋白 D 家族基因、16q23 (MAF)、20q11 (MAFB) 或 8q24 (MAFA) 上的 maf 家族基因或 4p16 上的 NSD2/FGFR3 基因失调,或者存在超二倍体。随后肿瘤抑制基因功能的丧失以及激活 MYC、RAS、NFkB 和细胞周期通路的突变与恶性疾病的进展有关。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.
期刊最新文献
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