Lingling Wu, Fenfang Su, Peixin Luo, Qingqing Dong, Mengni Ma, Guangyong Ye
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引用次数: 0
摘要
背景：富血小板血浆（PRP）是一种治疗方法，因其在治疗卵巢反应不良方面的潜力而备受关注。这项荟萃分析旨在系统回顾和分析临床研究，评估 PRP 对接受卵巢刺激进行试管婴儿的不良反应患者的影响：方法：在电子数据库（包括 PubMed、Embase、Scopus、Web of Science 和 Cochrane Library）中进行了全面检索，以确定以英文发表的相关研究。使用 R 4.2.3 版对妊娠结局、MII 卵母细胞数、可移植胚胎数和卵巢储备标志物等汇总数据进行分析：本荟萃分析共纳入了 10 项试验。经 PRP 治疗后，活产率为 16.6%（95% CI 8.8%-26.1%），临床妊娠率为 25.4%（95% CI 13.1%-39.9%）。PRP 预处理可增加 MII 卵母细胞数量（MD 1.073，95% CI 0.720 至 1.427）、胚胎数量（MD 0.946，95% CI 0.569 至 1.323）、前卵泡数量（MD 1.117；95% CI 0.689 至 1.544）以及激素水平的变化：结论：在本综述所评估的研究中，PRP对反应不佳者显示出了良好的效果。结论：在本综述所评估的研究中，PRP 对反应不佳者有良好的效果，但还需要进一步研究，以明确 PRP 在女性生殖健康中的潜在作用。
The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis.
Background: Platelet-rich plasma (PRP) is a therapeutic approach that is gaining attention for its potential in the treatment of poor ovarian response. This meta-analysis aimed to systematically review and analyze clinical studies to evaluate the impact of PRP on poor responders undergoing ovarian stimulation for IVF.
Methods: A comprehensive search was conducted in electronic databases, including PubMed, Embase, Scopus, Web of Science, and the Cochrane Library to identify relevant studies published in English. The pooled data, such as pregnancy outcome, number of MII oocytes, number of transferable embryos, and ovarian reserve markers were analyzed using R version 4.2.3.
Results: A total of 10 trials were enrolled in the present meta-analysis. Following PRP treatment, live birth rate was found to be 16.6% (95% CI 8.8%-26.1%), while clinical pregnancy rate was observed to be 25.4% (95% CI 13.1%-39.9%). PRP pretreatment resulted in a higher number of MII oocytes (MD 1.073, 95% CI 0.720 to 1.427), a higher number of embryos (MD 0.946, 95% CI 0.569 to 1.323), a higher antral follicle count (MD 1.117; 95% CI 0.689 to 1.544), and the change of hormone levels.
Conclusions: Among the studies evaluated in this review, PRP showed promising results in poor responder. Further research is required to clarify the potential role of PRP in female reproductive health.
期刊介绍：
Platelets is an international, peer-reviewed journal covering all aspects of platelet- and megakaryocyte-related research.
Platelets provides the opportunity for contributors and readers across scientific disciplines to engage with new information about blood platelets. The journal’s Methods section aims to improve standardization between laboratories and to help researchers replicate difficult methods.
Research areas include:
Platelet function
Biochemistry
Signal transduction
Pharmacology and therapeutics
Interaction with other cells in the blood vessel wall
The contribution of platelets and platelet-derived products to health and disease
The journal publishes original articles, fast-track articles, review articles, systematic reviews, methods papers, short communications, case reports, opinion articles, commentaries, gene of the issue, and letters to the editor.
Platelets operates a single-blind peer review policy. Authors can choose to publish gold open access in this journal.
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