HTLV-1感染的病毒学、发病机制、流行病学和临床管理。第 30 届 HTLV 欧洲研究网络(HERN 2023)会议记录

C. de Mendoza, Graham Taylor, A. Gessain, Andrea K. Thoma-Kress, Charles R. M. Bangham, Jan Vesterbacka, Roberto Accolla, Ali Bazarbachi, Jan van Weyenbergh, Lucy Cook, Jorge Casseb, Juan Carlos Ramos, Carolina Rosadas, Beatrice Macchi, O. Cassar, V. Soriano
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引用次数: 0

摘要

摘要 HTLV 欧洲研究网络(HERN)第 30 届研讨会于 2023 年 9 月 15-16 日在马德里举行。来自欧洲和美洲的 50 多名研究人员参加了为期两天的会议,更新并讨论了基础科学、流行病学、HTLV-1 感染患者的临床管理和治疗方法。会议讨论的科学主题包括:欧洲 HTLV-1 的新估计值;产前筛查对母婴 HTLV-1 感染的影响;HTLV-1 分子流行病学的新见解;HTLV-1 感染精英控制者的报告;抗逆转录病毒药物作为 HTLV-1 暴露前预防的作用;以及 HTLV-1 疫苗的前景。专家组同意向世卫组织提交一份正式请求,以加强全球对 HTLV-1 的监测和认识。这种病毒感染可能危及生命,但却被忽视,既没有治疗方法,也没有疫苗。目前,扩大 HTLV-1 筛查是减少病毒传播的最有效方法。
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Virology, pathogenesis, epidemiology and clinical management of HTLV-1 infection. Proceedings of the 30th HTLV European research network (HERN 2023)
Abstract The 30th workshop of the HTLV European Research Network (HERN) was held in Madrid on September 15–16, 2023. Over fifty researchers from Europe and America convened for a two-day conference to update and discuss basic science, epidemiology, clinical management and therapeutics for patients with HTLV-1 infection. Scientific topics addressed included new estimates for HTLV-1 in Europe; impact of antenatal screening on mother-to-child HTLV-1 infections; new insights into the molecular epidemiology of HTLV-1; reports of elite controllers for HTLV-1 infection; role of antiretrovirals as HTLV-1 pre-exposure prophylaxis; and prospects for a HTLV-1 vaccine. The group agreed to submit a formal request to WHO for increasing the global surveillance and awareness of HTLV-1. This viral infection is a potentially life-threatening, neglected condition with neither treatment nor vaccine. At this time, expanding HTLV-1 screening is the most effective way to reduce viral dissemination.
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