马钱子提取物对链脲佐菌素诱导的糖尿病大鼠的肾保护作用

IF 1.1 Q4 PHARMACOLOGY & PHARMACY Pharmacia Pub Date : 2024-01-09 DOI:10.3897/pharmacia.71.e113659
Raheeq Khairy Abdullah, Reem A. Issa, M. Abu-Samak, Beisan A. Mohammad, M. Abbas, S. Awwad
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引用次数: 0

摘要

糖尿病是一个普遍存在的健康问题,影响着全球各地的人们。本研究的目的是深入研究从苧麻的气生成分中提取的提取物在控制糖尿病肾病方面的优势。本研究采用植物化学和高效液相色谱法分析了苎麻提取物中的植物化学成分,重点分析了酚类和黄酮类化合物的含量。评估了植物提取物对链脲佐菌素诱导的糖尿病大鼠与糖尿病肾病相关的不同肾功能参数(空腹血糖、肌酐、尿酸和尿素)的影响。此外,还检测了肝脏的组织病理学变化。结果表明,E. ramosissimum 的甲醇和乙醇提取物中的酚类(相当于没食子酸,分别为 7.62 和 8.97 毫克/克)和黄酮类(相当于槲皮素,分别为 8.87 和 12.86 毫克/克)总含量较高。在进行超高效液相色谱-质谱/质谱分析后,发现甲醇和乙醇提取物中都含有异阿魏酸、ISO-Orientin、肉豆蔻酸、亚麻酸、芦丁和 3-Glu-7-Rha 槲皮素。此外,提取物中还含有异阿魏酸、肉豆蔻酸、木犀草酸、芦丁和 3-Glu-7-Rha 槲皮素。苎麻乙醇提取物对 STZ 诱导的糖尿病小鼠有明显影响,可降低其空腹血糖水平、肌酐和尿素水平(P < 0.005)。总之,E. ramosissimum 乙醇提取物显示出了对抗糖尿病对肾功能影响的潜在作用。因此,还需要进一步研究其对其他糖尿病相关并发症的影响。
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Nephroprotective effects of Equisetum ramosissimum L. extract in streptozotocin-induced diabetic rats
Diabetes is a widespread health issue that impacts people all over the globe. The Equisetum ramosissimum L. plant has numerous traditional uses and pharmacological properties, including antidiabetic effects.The objective of this study was to thoroughly examine the advantages of incorporating extracts from the aerial components of E. ramosissimum to control diabetic nephropathy. The phytochemical constituents of E. ramosissimum extract were explored using phytochemical and HPLC analysis, focusing on phenols and flavonoid content. The effect of plant extract was evaluated on different kidney function parameters linked to diabetic nephropathy (fasting blood glucose, creatinine, uric acid, and urea) in streptozotocin induced-diabetic rats. Histopathological changes in the liver were also examined. The results showed methanol and ethanol extracts of E. ramosissimum have a total content of phenols (equivalent to gallic acid, 7.62 and 8.97 mg/g) and flavonoids (equivalent to quercetin, 8.87 and 12.86 mg/g), respectively. After conducting the UHPLC-MS/MS analysis, it was found that both the methanol and ethanol extracts contained isoferulic acid, ISO-Orientin, myristic acid, linoelaidic acid, rutin, and 3-Glu-7-Rha quercetin. Additionally, isoferulic acid, myristic acid, linoelaidic acid, rutin, and 3-Glu-7-Rha quercetin were present in the extracts. The ethanol extract of E. ramosissimum significantly impacted STZ-induced diabetic mice by reducing their fasting blood glucose levels, and their creatinine and urea levels (P < 0.005). In conclusion, E. ramosissimum ethanol extract has shown potential effects to counteract some diabetes consequences on kidney function. Therefore, further studies are required to investigate its effect on other diabetes-related complications.
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来源期刊
Pharmacia
Pharmacia PHARMACOLOGY & PHARMACY-
CiteScore
2.30
自引率
27.30%
发文量
114
审稿时长
12 weeks
期刊最新文献
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