印度农村非痴呆者、中年人和老年人载脂蛋白E ε4基因型与注意力功能的关系

IF 0.8 Q4 CLINICAL NEUROLOGY Journal of Neurosciences in Rural Practice Pub Date : 2024-01-09 DOI:10.25259/jnrp_272_2023
Pooja Rai, Jonas S. Sundarakumar, Nimisha Basavaraju, R. Kommaddi, T. Issac
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引用次数: 0

摘要

有几种遗传因素与老年认知能力下降有关。载脂蛋白 E(载脂蛋白 E)ε4 与包括痴呆症在内的病理认知能力衰退风险的关系已被广泛研究。本研究旨在研究印度农村人口中的载脂蛋白 E 基因型与老年人(≥45 岁)的注意力功能之间的关系。横断面(基线)数据(n = 2100)来自一项正在进行的老龄化纵向队列研究(Srinivaspura Aging, Neurosenescence, and Cognition study)。参与者来自印度南部卡纳塔克邦斯里尼瓦斯普拉的村庄。根据载脂蛋白E-ε4的状态将参与者分为三类:无ε4、杂合子ε4和同合子ε4。注意力功能通过计算机化神经认知测试中的听觉和视觉注意力子测试进行评估。在模型1(未调整)中,我们没有发现载脂蛋白E与注意力功能之间的关系。在部分调整后的模型 2(调整年龄)中,载脂蛋白E ε4与年龄的关系与注意力功能显著相关。此外,随着年龄的增长,同卵ε4个体的注意力下降。模型 3(模型 2 + 性别)发现,载脂蛋白 E ε4、年龄和性别解释了注意力功能的显著差异。此外,随着年龄的增长,与杂合子组相比,同合子组男性的注意力较差。模型4(模型3+教育程度)解释了注意力的显著差异,还显示随着年龄的增长,在同卵和杂合子组中,文盲和低文化程度组的男女注意力都有所下降。对认知能力的纵向监测将有助于了解载脂蛋白E ε4基因型是否会影响这一农村老龄人口的认知能力衰退速度。
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Association between ApoE ε4 genotype and attentional function in non-demented, middle-aged, and older adults from rural India
Several genetic factors have been associated with cognitive decline in aging. Apolipoprotein E (ApoE) ε4 has been widely studied in the risk for pathological cognitive decline, including dementia. However, the association between ApoE ε4 and cognitive functioning in the healthy aging Indian population has been understudied, and the results are ambiguous. This study aims to examine the role of the ApoE genotype with attentional function in aging adults (≥45 years) in a rural Indian population. Cross-sectional (baseline) data (n = 2100) was utilized from an ongoing longitudinal cohort study on aging (Srinivaspura Aging, Neurosenescence, and Cognition study). Participants hailed from villages of Srinivaspura in Karnataka, southern India. Participants were categorized based on ApoE-ε4 status into three categories: No ε4, heterozygous ε4, and homozygous ε4. Attentional function was assessed using the auditory and visual attention subtests from a computerized neurocognitive test battery. Linear regression was performed adjusting for age, gender, and education. In model 1 (unadjusted), we did not find an association between ApoE and attention function. In the partially adjusted model 2 (adjusting for age), ApoE ε4 with age was significantly associated with the attention function. Further, with increasing age, there was a decline in attention among homozygous ε4 individuals. Model 3 (model 2 + gender) found that ApoE ε4, age, and gender explained a significant variance in attention function. In addition, with increasing age, males had poor attention in the homozygous as compared to heterozygous group. Model 4 (model 3+ education) explained a significant variance in attention and also revealed that with increasing age, attention declined in the illiterate and low literacy groups in both homozygous and heterozygous groups among both genders. Although ApoE ε4 alone was not associated, it interacted with age, gender, and education to affect attention function in this rural Indian population. Longitudinal cognitive monitoring will yield insights into understanding whether the ApoE ε4 genotype influences the rate of cognitive decline in this rural, aging population.
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129
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22 weeks
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