利用控制系统工程控制 COVID-19 爆发的公共决策政策

COVID Pub Date : 2024-01-08 DOI:10.3390/covid4010005
H. Patiño, J. Pucheta, Cristian Rodríguez Rivero, Santiago Tosetti
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引用次数: 0

摘要

这项工作是对各国际卫生组织和自动控制界呼吁合作应对大流行初期冠状病毒/COVID-19 挑战的回应。具体来说,本研究提出了科学证据,支持缓解大流行的三种主要非药物策略的有效性。我们提出了一个控制系统,以帮助制定公共决策政策,管理由 SARS-CoV-2 病毒(俗称冠状病毒)引起的 COVID-19 的传播。其主要目的是通过避免重症监护室(ICU)的饱和来防止医疗系统不堪重负。在 COVID-19 的背景下,了解高峰感染率及其时间延迟对于准备医疗基础设施和确保配备自动呼吸机的重症监护室的充足供应至关重要。虽然人们普遍认为,包括隔离和社会疏远在内的公共政策可以拉平流行病学曲线,并为加强医疗资源提供时间,但从控制系统理论的角度来研究这一关键问题的研究还很缺乏。在本研究中,我们介绍了一种控制系统,该系统建立在三种流行病和大流行病缓解的常用非药物工具之上:社会隔离、封闭以及在出现社区传播的地区进行全人群检测和隔离。我们的分析和控制系统设计依赖于易感者-暴露者-感染者-康复者-死亡者(SEIRD)数学模型,该模型描述了大流行的时间动态,本研究根据 SARS-CoV-2 行为的时间和空间特征进行了调整。该模型纳入了进行试验和随后的人群隔离的影响。对开关控制策略进行了分析,并提出了一个比例-积分-派生(PID)控制器来生成一系列公共政策决策。建议的控制系统采用所需的危重病床和重症监护室数量作为反馈信号,并将其与可用病床容量进行比较,以产生误差信号,该误差信号被用作 PID 控制器的输入信号。概述的控制行动涉及政府当局实施的五个 "社会隔离和封闭"(SD&C)阶段。因此,控制系统会生成一个 SD&C 政策序列,每周或每两周应用一次。模拟结果强调了这三种缓解策略对冠状病毒的有利影响,说明了它们在控制疫情爆发方面的功效,从而降低了医疗系统崩溃的风险。
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Public Decision Policy for Controlling COVID-19 Outbreaks Using Control System Engineering
This work is a response to the appeal of various international health organizations and the Automatic Control Community for collaboration in addressing Coronavirus/COVID-19 challenges during the initial stages of the pandemic. Specifically, this study presents scientific evidence supporting the efficacy of three primary non-pharmacological strategies for pandemic mitigation. We propose a control system to aid in formulating a public decision policy aimed at managing the spread of COVID-19 caused by the SARS-CoV-2 virus, commonly known as coronavirus. The primary objective is to prevent overwhelming healthcare systems by averting the saturation of intensive care units (ICUs). In the context of COVID-19, understanding the peak infection rate and its time delay is crucial for preparing healthcare infrastructure and ensuring an adequate supply of intensive care units equipped with automatic ventilators. While it is widely recognized that public policies encompassing confinement and social distancing can flatten the epidemiological curve and provide time to bolster healthcare resources, there is a dearth of studies examining this pivotal issue from the perspective of control system theory. In this study, we introduce a control system founded on three prevailing non-pharmacological tools for epidemic and pandemic mitigation: social distancing, confinement, and population-wide testing and isolation in regions experiencing community transmission. Our analysis and control system design rely on the susceptible-exposed–infected–recovered–deceased (SEIRD) mathematical model, which describes the temporal dynamics of a pandemic, tailored in this research to account for the temporal and spatial characteristics of SARS-CoV-2 behavior. This model incorporates the influence of conducting tests with subsequent population isolation. An On–off control strategy is analyzed, and a proportional–integral–derivative (PID) controller is proposed to generate a sequence of public policy decisions. The proposed control system employs the required number of critical beds and ICUs as feedback signals and compares these with the available bed capacity to generate an error signal, which is utilized as input for the PID controller. The control actions outlined involve five phases of “Social Distancing and Confinement” (SD&C) to be implemented by governmental authorities. Consequently, the control system generates a policy sequence for SD&C, with applications occurring on a weekly or biweekly basis. The simulation results underscore the favorable impact of these three mitigation strategies against the coronavirus, illustrating their efficacy in controlling the outbreak and thereby mitigating the risk of healthcare system collapse.
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