结核病流行病学监测:从分子方法到基因组研究

O. Ogarkov, E. Savilov, S. Zhdanova
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引用次数: 0

摘要

相关性。分子和基因组分析方法是信息量最大的方法,可从根本上改变对该疾病的管理。证明在俄罗斯和前苏联国家进行分子研究以彻底检测结核分枝杆菌的大多数流行基因型是必要且足够的。L2(北京)和 L4(欧美)基因系覆盖了俄罗斯和前苏联国家 95% 以上的结核分枝杆菌流行基因型。开发出与全球基因组多态性数据兼容的快速检测方法,将有可能对国内结核病疫情进行流行病学分析,并区别新基因型的跨境传播情况。
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Epidemiological Surveillance of Tuberculosis: from Molecular Methods to Genomic Studies
Relevance. The globalization of the epidemic process requires improved surveillance of infectious diseases, in particular tuberculosis.Methods of molecular and genomic analysis are the most informative approaches that can radically change the management of this disease.Aims. To substantiate the necessary and sufficient volume of molecular studies for the exhaustive detection of most epidemic genotypes of Mycobacterium tuberculosis in Russia and the countries of the former USSR.Conclusions. Genetic lines L2 (Beijing) and L4 (Euro-American) cover more than 95% of all epidemic genotypes of M. tuberculosis in Russia and the countries of the former USSR. The development of rapid tests compatible with global data on genomic polymorphism will make it possible to conduct an epidemiological analysis of tuberculosis outbreaks within the country and to differ from cases of transbordern transmission of new genotypes outside.
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