人类新生儿中危及生命的感染:调和特定年龄的易感性和个体间的变异性

IF 3.7 4区 医学 Q2 CELL BIOLOGY Cellular immunology Pub Date : 2024-01-13 DOI:10.1016/j.cellimm.2024.104807
Alessandro Borghesi
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引用次数: 0

摘要

人类在接触微生物后,临床结果的个体差异非常大,从无声感染到危及生命的疾病,不一而足。年龄特异性免疫反应是造成新生儿出生后 28 天内高感染率和相关高死亡率的部分原因。然而,危及生命的疾病在个别新生儿中的发生仍无法解释。与此相反,在儿童和成人中发现的先天性免疫错误及其免疫表型越来越多,病毒、细菌、霉菌和真菌感染都会危及生命。新生儿免疫学对新生儿特异性免疫反应进行了深入的群体特征描述,而临床免疫学则对患者的感染进行了细胞和分子水平的研究,这两个领域需要相互融合,以促进确定新生儿个体易受感染的机制,并设计新的预防和治疗策略。
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Life-threatening infections in human newborns: Reconciling age-specific vulnerability and interindividual variability

In humans, the interindividual variability of clinical outcome following exposure to a microorganism is immense, ranging from silent infection to life-threatening disease. Age-specific immune responses partially account for the high incidence of infection during the first 28 days of life and the related high mortality at population level. However, the occurrence of life-threatening disease in individual newborns remains unexplained. By contrast, inborn errors of immunity and their immune phenocopies are increasingly being discovered in children and adults with life-threatening viral, bacterial, mycobacterial and fungal infections. There is a need for convergence between the fields of neonatal immunology, with its in-depth population-wide characterization of newborn-specific immune responses, and clinical immunology, with its investigations of infections in patients at the cellular and molecular levels, to facilitate identification of the mechanisms of susceptibility to infection in individual newborns and the design of novel preventive and therapeutic strategies.

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来源期刊
Cellular immunology
Cellular immunology 生物-免疫学
CiteScore
8.20
自引率
2.30%
发文量
102
审稿时长
30 days
期刊介绍: Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.
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