Rou Zheng , Yan Ren , Xinyue Liu , Canxia He , Hua Liu , Yixuan Wang , Jianing Li , Shuya Xia , Zhifang Liu , Yizhao Ma , Dianchen Wang , Suling Xu , Geng Wang , Na Li
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引用次数: 0
摘要
特应性皮炎(AD)是一种以剧烈瘙痒为特征的炎症性皮肤病。特应性皮炎对儿童和成人都有害,但其致病机制尚未完全阐明。小鼠皮炎模型的开发极大地促进了皮炎的研究和治疗。在这些模型中,外源性药物诱导小鼠模型显示出了良好的效果和显著的优势。迄今为止,大量与阿德相关的研究都采用了外源性药物诱导小鼠模型,从而取得了显著的研究进展。这表明将此类模型应用于注意力缺失症研究具有至关重要的意义。这些模型表现出多种多样的特点,而且非常复杂。它们涉及使用不同品系的小鼠、不同类型的诱导剂和不同的建模效果。然而,目前缺乏关于外源性药物诱导的 AD 小鼠模型的全面比较研究,这阻碍了研究人员在这些模型中进行选择。本文全面综述了各种外源性药物诱导的小鼠模型的特点和相关机制,包括每种细胞因子在AD发展过程中的重要作用。它旨在帮助研究人员快速了解模型,并选择最合适的模型进行进一步研究。
Exogenous drug-induced mouse models of atopic dermatitis
Atopic dermatitis (AD) is an inflammatory skin disease characterized by intense pruritus. AD is harmful to both children and adults, but its pathogenic mechanism has yet to be fully elucidated. The development of mouse models for AD has greatly contributed to its study and treatment. Among these models, the exogenous drug-induced mouse model has shown promising results and significant advantages. Until now, a large amount of AD-related research has utilized exogenous drug-induced mouse models, leading to notable advancements in research. This indicates the crucial significance of applying such models in AD research. These models exhibit diverse characteristics and are highly complex. They involve the use of various strains of mice, diverse types of inducers, and different modeling effects. However, there is currently a lack of comprehensive comparative studies on exogenous drug-induced AD mouse models, which hinders researchers' ability to choose among these models. This paper provides a comprehensive review of the features and mechanisms associated with various exogenous drug-induced mouse models, including the important role of each cytokine in AD development. It aims to assist researchers in quickly understanding models and selecting the most suitable one for further investigation.
期刊介绍:
Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews.
We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine.
By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.