药用植物在改善伤口愈合技术方面的挑战性作用综述。

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY DARU Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 Epub Date: 2024-01-15 DOI:10.1007/s40199-023-00502-x
Deepika Pathak, Avijit Mazumder
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引用次数: 0

摘要

目的:慢性疾病往往会阻碍伤口的自然愈合过程,使伤口感染成为临床上普遍关注的问题。严重时还会出现并发症,有可能导致致命后果。虽然对抗疗法为伤口修复和管理提供了多种选择,但中草药之所以经久不衰,可能是由于它们被认为副作用最小。因此,本综述旨在研究草药在有效治疗伤口方面的潜力,为人们提供一种值得考虑的替代疗法:方法:进行文献检索,包括研究、综述、系统文献综述、荟萃分析和临床试验。检索数据时使用了 Pubmed、Google Scholar 和 Scopus 等搜索引擎。使用了 "伤口愈合"、"伤口愈合与草药组合"、"草药伤口敷料"、纳米技术和伤口敷料等关键词:结果:这篇综述对天然产品和技术配方在治疗伤口感染中的作用提供了有价值的见解。它评估了草药疗法作为一种有效方法的使用情况。草药中的黄酮类、苷类、皂苷类和酚类化合物等各种活性成分在促进伤口闭合方面显示出了有效性。多种草药在伤口处理方面具有显著疗效,为护理提供了新的途径。本综述共包括 72 项研究,涉及 127 种不同的草药(不包括研究之间共享的任何普通草药),主要属于菊科、豆科和繖形花科。在研究中,主要利用大鼠模型来评估伤口愈合活性。此外,使用纳米技术伤口敷料材料(如纳米纤维、纳米乳液、纳米纤维垫、聚合物纤维和水凝胶微针)的草药制剂也在不断进步。这些创新旨在加强靶向给药,加快伤口恢复。已有多项临床实验研究对各种天然产品在伤口护理和管理方面的功效进行了评估。这标志着伤口治疗领域的一个充满希望的方向:近年来,科学家们越来越多地利用循证医学和先进的科学技术来验证草药的功效,并深入研究其作用的内在机制。然而,要彻底了解从草药中提取的分离化学物质是如何促进复杂伤口的愈合过程(这些伤口可能会危及生命),仍亟需进一步研究。这项正在进行的研究工作不仅有望加深我们的理解,而且有望开发出加快伤口愈合过程的创新配方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.

Purpose: Chronic diseases often hinder the natural healing process, making wound infections a prevalent clinical concern. In severe cases, complications can arise, potentially leading to fatal outcomes. While allopathic treatments offer numerous options for wound repair and management, the enduring popularity of herbal medications may be attributed to their perceived minimal side effects. Hence, this review aims to investigate the potential of herbal remedies in efficiently treating wounds, presenting a promising alternative for consideration.

Methods: A literature search was done including research, reviews, systematic literature review, meta-analysis, and clinical trials considered. Search engines such as Pubmed, Google Scholar, and Scopus were used while retrieving data. Keywords like Wound healing 'Wound healing and herbal combinations', 'Herbal wound dressing', Nanotechnology and Wound dressing were used.

Result: This review provides valuable insights into the role of natural products and technology-based formulations in the treatment of wound infections. It evaluates the use of herbal remedies as an effective approach. Various active principles from herbs, categorized as flavonoids, glycosides, saponins, and phenolic compounds, have shown effectiveness in promoting wound closure. A multitude of herbal remedies have demonstrated significant efficacy in wound management, offering an additional avenue for care. The review encompasses a total of 72 studies, involving 127 distinct herbs (excluding any common herbs shared between studies), primarily belonging to the families Asteraceae, Fabaceae, and Apiaceae. In research, rat models were predominantly utilized to assess wound healing activities. Furthermore, advancements in herbal-based formulations using nanotechnology-based wound dressing materials, such as nanofibers, nanoemulsions, nanofiber mats, polymeric fibers, and hydrogel-based microneedles, are underway. These innovations aim to enhance targeted drug delivery and expedite recovery. Several clinical-based experimental studies have already been documented, evaluating the efficacy of various natural products for wound care and management. This signifies a promising direction in the field of wound treatment.

Conclusion: In recent years, scientists have increasingly utilized evidence-based medicine and advanced scientific techniques to validate the efficacy of herbal medicines and delve into the underlying mechanisms of their actions. However, there remains a critical need for further research to thoroughly understand how isolated chemicals extracted from herbs contribute to the healing process of intricate wounds, which may have life-threatening consequences. This ongoing research endeavor holds great promise in not only advancing our understanding but also in the development of innovative formulations that expedite the recovery process.

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DARU Journal of Pharmaceutical Sciences
DARU Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-
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期刊介绍: DARU Journal of Pharmaceutical Sciences is a peer-reviewed journal published on behalf of Tehran University of Medical Sciences. The journal encompasses all fields of the pharmaceutical sciences and presents timely research on all areas of drug conception, design, manufacture, classification and assessment. The term DARU is derived from the Persian name meaning drug or medicine. This journal is a unique platform to improve the knowledge of researchers and scientists by publishing novel articles including basic and clinical investigations from members of the global scientific community in the forms of original articles, systematic or narrative reviews, meta-analyses, letters, and short communications.
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