心脏代谢合并症对银屑病生物治疗 PASI 评分的影响:定性系统综述

IF 5.2 Q1 DERMATOLOGY Psoriasis (Auckland, N.Z.) Pub Date : 2024-01-10 eCollection Date: 2024-01-01 DOI:10.2147/PTT.S441642
Alim Osman, Alexandra Nigro, Amanda Chen Taylor, Ryan Saal, Ana Ormaza Vera, Clinton Enos
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引用次数: 0

摘要

目的:研究表明,心脏代谢风险因素会降低炎症患者的生物疗效。本系统综述的目的是对有心脏代谢合并症的银屑病患者的生物反应研究进行定性评估:方法:根据《系统综述和荟萃分析首选报告指南》(Preferred Reporting Guidelines for Systematic Reviews and Meta-Analysis)进行全面综述,筛选出包括具有心脏代谢风险因素的银屑病患者接受生物制剂治疗的研究。未采用银屑病面积和严重程度指数(PASI)评分来评估治疗效果的研究未被纳入。所有研究均采用非随机研究方法指数(MINORS)量表进行了质量/偏倚分析:结果:肥胖和体重指数(BMI)是研究最多的心脏代谢风险因素。大多数研究报告称,随着体重指数/肥胖率的增加,达到 PASI75 和 PASI90 反应的频率降低。糖尿病和高血压也有类似的研究结果,但研究频率较低。对高脂血症和其他血脂紊乱的研究较少:结论:在目前的文献中,心脏代谢风险因素与较低的 PASI75/90 达标率之间存在关系。这篇定性系统综述报告了存在心脏代谢风险因素时 PASI75 和 PASI90 达标率较低的证据。
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The Effects of Cardiometabolic Comorbidities on Biologic Treatment for Psoriasis with Respect to PASI Scores: A Qualitative Systematic Review.

Objective: Cardiometabolic risk factors have been shown to decrease biologic efficacy in patients treated for inflammatory conditions. The purpose of this systematic review is to provide a qualitative evaluation of studies investigating biologic response among psoriasis patients with cardiometabolic comorbidities.

Methods: A comprehensive review was conducted according to the Preferred Reporting Guidelines for Systematic Reviews and Meta-Analysis guidelines to screen for studies including patients with cardiometabolic risk factors receiving biologic therapy for psoriasis. Studies not including a Psoriasis Area and Severity Index (PASI) score to evaluate treatment outcomes were not included. All studies underwent quality/bias analysis using the Methodological Index for Non-Randomized Studies (MINORS) scale.

Results: Obesity and Body Mass Index (BMI) were the most studied cardiometabolic risk factors. The majority of the studies reported a lower frequency of achieving PASI75 and PASI90 response with increasing BMI/obesity rates. Diabetes and hypertension showed similar findings but were not studied as frequently. Hyperlipidemia and other lipid disorders were less frequently studied.

Conclusion: Relationships between cardiometabolic risk factors and lower frequencies of achieving PASI75/90 exist in current literature. This qualitative systematic review reports evidence of lower PASI75 and PASI90 response rates in the presence of cardiometabolic risk factors.

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期刊最新文献
Metabolic Syndrome in Psoriasis and Psoriatic Arthritis in a Mixed Race Population: Comparison of Their Prevalences. Do NSAIDs Trigger or Exacerbate Psoriasis? [Response to Letter]. Secukinumab Causing Medication-Related Osteonecrosis of the Jaw, in a Patient Diagnosed with Psoriasis and Rheumatoid Arthritis. Tobacco Smoking Interacted with Alcohol Drinking Could Increase the Failure of PASI75 Achievement at Week 8 Among Patients with Psoriasis: Findings Based on a Psoriasis Cohort. NSAIDs: Unveiling Their Role in Drug-Induced Psoriasis [Letter].
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