伊曲康唑减敏马杜氏菌 CBS 129176 型菌株的完整基因组序列。

IF 3.6 3区生物学 Q2 MYCOLOGY Mycopathologia Pub Date : 2024-01-17 DOI:10.1007/s11046-023-00807-0

Mickey Konings, Bert Gerrits van den Ende, Mirthe W J Raats, Ahmed Hassan Fahal, Wendy W J van de Sande, Ferry Hagen

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引用次数: 0

摘要

法氏马杜雷拉菌（Madurella fahalii）是种植性霉菌病霉菌瘤的致病菌，它对伊曲康唑的敏感性降低，而伊曲康唑是防治霉菌瘤的首选治疗药物。在此，我们报告了 M. fahalii 型菌株 CBS 129176 的基因组组装和注释，以确定 Cyp51A 蛋白中唑结合口袋附近的谷氨酸插入物。

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Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176.

Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.

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来源期刊

Mycopathologia 生物-真菌学

CiteScore

6.80

自引率

3.60%

发文量

审稿时长

3 months

期刊介绍： Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.