心力衰竭患者估计脉搏波速度与全因死亡之间的关系

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Revista clinica espanola Pub Date : 2024-01-01 DOI:10.1016/j.rce.2023.11.009

X. Yuan , C. Chen , J. Mao , W. Bao , C. Chen , T. Xu

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引用次数: 0

摘要

背景动脉硬化已被证实是心力衰竭发病和再入院的风险因素。ePWV是一种新型的无创、简单的动脉僵化指标，本研究旨在探讨其与心力衰竭患者全因死亡率的关系。方法本研究是一项队列研究，纳入了1999年至2018年NHANES数据中的1272名心力衰竭患者。将 ePWV 分成三组，利用 KM 生存曲线计算心衰患者的累积死亡率。心衰患者 ePWV 与全因死亡率之间的关系用平滑曲线拟合表示。结果研究对象的平均年龄为（67.8 ± 12.6）岁，其中男性 862 人，女性 650 人。在12个月的随访期间，全因死亡率为790例。研究人员采用 Cox 回归分析验证了心衰患者 ePWV 与全因死亡率之间的关系。ePWV 水平越高的患者全因死亡率越高。在对多种因素进行调整后，ePWV 的增加与全因死亡率呈正相关（HR = 1.17，95% 置信区间 [CI]：1.12-1.22）。与最低三分位数相比，最高三分位数 ePWV 的多变量调整 HR 和 95% CI 分别为 1.81（95% CI：1.45-2.27）。此外，还使用平滑曲线拟合来观察 ePWV 与死亡率之间的关系，曲线显示 ePWV 与全因死亡率呈正相关。此外，KM 生存曲线表明，全因死亡率随着 ePWV 的增加而增加。结论我们的研究表明，ePWV 与心衰患者的全因死亡率呈正相关。

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Asociación entre la velocidad estimada de onda de pulso y la muerte por todas las causas en pacientes con insuficiencia cardiaca

Background

Arteriosclerosis has been proven to be a risk factor for the development of heart failure and readmission. ePWV is a novel non-invasive and simple indicator of arterial stiffness, and this study aims to investigate its relationship with all-cause mortality rate in patients with heart failure.

Methods

This study is a cohort study that included 1272 patients with heart failure from NHANES data from 1999 to 2018. The ePWV was divided into three groups, and the cumulative mortality rate of heart failure patients was calculated using KM survival curves. The relationship between ePWV and all-cause mortality rate in heart failure patients was represented by a smoothed curve fitting. COX regression analysis was used to assess the association between ePWV and all-cause mortality rate in heart failure patients.

Results

The average age of the study population was 67.8 ± 12.6 years, with 862 males and 650 females. During the 12-month follow-up period, there were 790 cases of all-cause mortality. Cox regression analysis was used to validate the relationship between ePWV and all-cause mortality rate in patients with heart failure. Patients with higher levels of ePWV tended to have a higher all-cause mortality rate. After adjustment for multiple factors, an increase in ePWV was positively associated with all-cause mortality rate (HR = 1.17, 95% confidence interval [CI]: 1.12-1.22). Compared to the lowest tertile, the multivariable-adjusted HR and 95% CI for the highest tertile of ePWV were 1.81 (95% CI: 1.45-2.27). Additionally, a smoothed curve fitting was used to observe the relationship between ePWV and mortality rate, where the curve demonstrated a positive correlation between ePWV and all-cause mortality rate. Furthermore, KM survival curves indicated that all-cause mortality rate increased with the increase in ePWV. Subgroup analysis suggested a correlation between ePWV and mortality rate.

Conclusion

Our study shows that ePWV is positively associated with all-cause mortality in patients with heart failure.

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来源期刊

Revista clinica espanola 医学-医学：内科

CiteScore

4.40

自引率

6.90%

发文量

审稿时长

28 days

期刊介绍： Revista Clínica Española published its first issue in 1940 and is the body of expression of the Spanish Society of Internal Medicine (SEMI). The journal fully endorses the goals of updating knowledge and facilitating the acquisition of key developments in internal medicine applied to clinical practice. Revista Clínica Española is subject to a thorough double blind review of the received articles written in Spanish or English. Nine issues are published each year, including mostly originals, reviews and consensus documents.