以 2-碘苯甲酰胺为催化剂和 Oxone，高效且环保地氧化裂解吡咯烷-2-甲醇至 γ-内酰胺

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL Chemical & pharmaceutical bulletin Pub Date : 2024-01-17 DOI:10.1248/cpb.c23-00742

Hema Naga Lakshmi Perumalla, Tomoya Fujiwara, Maki Okada, Kanna Asakubo, Takashi Okitsu, Kengo Kasama, Hisanori Nambu, Takayuki Yakura

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引用次数: 0

摘要

有人描述了将吡咯烷-2-甲醇氧化裂解为 γ-内酰胺的反应。在该反应中，[4-碘-3-（异丙基氨基甲酰基）苯氧基]乙酸和粉末 Oxone（2KHSO5-KHSO4-K2SO4）分别用作催化剂和助氧化剂。该反应利用有机催化剂和无机无毒助氧化剂，以中等到极好的产率从容易获得的底物制备出各种内酰胺，因此高效且对环境无害。

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Efficient and Environmentally Benign Oxidative Cleavage of Pyrrolidine-2-methanols to γ-Lactams Using 2-Iodobenzamide as a Catalyst and Oxone

The oxidative cleavage reaction of pyrrolidine-2-methanols to γ-lactams has been described. In this reaction, [4-iodo-3-(isopropylcarbamoyl)phenoxy]acetic acid and powdered Oxone (2KHSO₅·KHSO₄·K₂SO₄) were employed as the catalyst and co-oxidant, respectively. The reaction is efficient and environmentally benign because it produces various lactams from readily available substrates in moderate to excellent yields using organocatalyst and inorganic non-toxic co-oxidant.

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.