{"title":"基于正念的认知疗法促进肝移植受者坚持免疫抑制治疗：随机对照试验","authors":"Semra Bulbuloglu , Hüseyin Gunes","doi":"10.1016/j.explore.2024.01.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study was to analyze the effects of mindfulness-based cognitive therapy on the adherence of liver transplant recipients to immunosuppressive therapy with a randomized controlled design.</p></div><div><h3>Method</h3><p>This randomized controlled trial was performed with 120 liver transplant recipients hospitalized at the liver transplant department of a research and practice hospital (<em>n</em> = 120). While we administered no intervention to the patients in the control group (<em>n</em> = 60), we provided Mindfulness-Based Cognitive Therapy to those in the experimental group (<em>n</em> = 60). We used the Mindful Attention Awareness Scale and the Immunosuppressant Therapy Adherence Scale to collect data. We utilized descriptive statistics, paired-samples <em>t</em>-tests, independent-samples <em>t</em>-tests, one-way analysis of variance, and chi-squared tests to analyze the data.</p></div><div><h3>Results</h3><p>After the intervention, the immunosuppressive therapy adherence levels of the experimental group increased significantly (<em>p</em> < 0.01). On the other hand, the control group had significantly higher adherence to immunosuppressive therapy and significantly higher levels of mindfulness in the pretest phase than it did in the posttest phase (<em>p</em> < 0.01).</p></div><div><h3>Conclusions</h3><p>Complete adherence to immunosuppressive therapy is imperative for the prevention of graft rejection in liver transplant recipients. In our study, the experimental group equipped with enhanced mindfulness had higher adherence to immunosuppressive therapy. Therefore, the use of Mindfulness-Based Cognitive Therapy in the promotion of adherence to immunosuppressive therapy is recommended.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mindfulness-based cognitive therapy for adherence of immunosuppressive treatment in liver transplant recipients: A randomized controlled trial\",\"authors\":\"Semra Bulbuloglu , Hüseyin Gunes\",\"doi\":\"10.1016/j.explore.2024.01.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>The aim of this study was to analyze the effects of mindfulness-based cognitive therapy on the adherence of liver transplant recipients to immunosuppressive therapy with a randomized controlled design.</p></div><div><h3>Method</h3><p>This randomized controlled trial was performed with 120 liver transplant recipients hospitalized at the liver transplant department of a research and practice hospital (<em>n</em> = 120). While we administered no intervention to the patients in the control group (<em>n</em> = 60), we provided Mindfulness-Based Cognitive Therapy to those in the experimental group (<em>n</em> = 60). We used the Mindful Attention Awareness Scale and the Immunosuppressant Therapy Adherence Scale to collect data. We utilized descriptive statistics, paired-samples <em>t</em>-tests, independent-samples <em>t</em>-tests, one-way analysis of variance, and chi-squared tests to analyze the data.</p></div><div><h3>Results</h3><p>After the intervention, the immunosuppressive therapy adherence levels of the experimental group increased significantly (<em>p</em> < 0.01). On the other hand, the control group had significantly higher adherence to immunosuppressive therapy and significantly higher levels of mindfulness in the pretest phase than it did in the posttest phase (<em>p</em> < 0.01).</p></div><div><h3>Conclusions</h3><p>Complete adherence to immunosuppressive therapy is imperative for the prevention of graft rejection in liver transplant recipients. In our study, the experimental group equipped with enhanced mindfulness had higher adherence to immunosuppressive therapy. 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引用次数: 0
摘要
研究目的本研究旨在通过随机对照设计，分析正念认知疗法对肝移植受者坚持免疫抑制治疗的影响：这项随机对照试验的对象是在一家研究与实践医院肝移植科住院的120名肝移植受者（n=120）。对照组患者（60 人）未接受任何干预，而实验组患者（60 人）接受了正念认知疗法。我们使用正念注意力认知量表和免疫抑制剂治疗依从性量表来收集数据。我们采用了描述性统计、配对样本 t 检验、独立样本 t 检验、单因素方差分析和卡方检验来分析数据：结果：干预后，实验组的免疫抑制治疗依从性水平显著提高（p<0.01）。另一方面，对照组在前测阶段的免疫抑制治疗依从性和正念水平明显高于后测阶段（p<0.01）：完全坚持免疫抑制治疗对于预防肝移植受者的移植物排斥反应至关重要。在我们的研究中，配备强化正念的实验组对免疫抑制治疗的依从性更高。因此，建议使用正念认知疗法来促进免疫抑制治疗的依从性。
Mindfulness-based cognitive therapy for adherence of immunosuppressive treatment in liver transplant recipients: A randomized controlled trial
Objective
The aim of this study was to analyze the effects of mindfulness-based cognitive therapy on the adherence of liver transplant recipients to immunosuppressive therapy with a randomized controlled design.
Method
This randomized controlled trial was performed with 120 liver transplant recipients hospitalized at the liver transplant department of a research and practice hospital (n = 120). While we administered no intervention to the patients in the control group (n = 60), we provided Mindfulness-Based Cognitive Therapy to those in the experimental group (n = 60). We used the Mindful Attention Awareness Scale and the Immunosuppressant Therapy Adherence Scale to collect data. We utilized descriptive statistics, paired-samples t-tests, independent-samples t-tests, one-way analysis of variance, and chi-squared tests to analyze the data.
Results
After the intervention, the immunosuppressive therapy adherence levels of the experimental group increased significantly (p < 0.01). On the other hand, the control group had significantly higher adherence to immunosuppressive therapy and significantly higher levels of mindfulness in the pretest phase than it did in the posttest phase (p < 0.01).
Conclusions
Complete adherence to immunosuppressive therapy is imperative for the prevention of graft rejection in liver transplant recipients. In our study, the experimental group equipped with enhanced mindfulness had higher adherence to immunosuppressive therapy. Therefore, the use of Mindfulness-Based Cognitive Therapy in the promotion of adherence to immunosuppressive therapy is recommended.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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