美洛昔康或罗苯昔布给药时间对卵巢切除术猫肾功能和术后镇痛的影响:随机、盲法对照临床试验。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-01-18 DOI:10.1111/jvp.13427
Alex Krekis, Jonathan N. King, Duncan D'Arcy-Howard, Nadene Stapleton, Jonathan Elliott, Ludovic Pelligand
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摘要

我们在一项前瞻性随机盲法对照研究中评估了美洛昔康和罗苯那考昔给药时间对 60 只接受卵巢切除术的猫肾功能、血小板环氧化酶和围手术期镇痛的影响。12 只猫被随机分配到一个皮下治疗组:入院时(MA、RA)、诱导时(MI、RI)使用美洛昔康(0.2 mg/kg)或罗贝那昔布(2 mg/kg),手术结束时(RE)使用罗贝那昔布。所有猫都接受了相同的麻醉方案。依次测量血浆肾素活性(PRA)、血浆肌酐、药物浓度和血清血栓素(TxB2)。麻醉会明显增加肾素活性,因为手术结束时的肾素活性高于手术后 2 小时(平均值 ± SD:26.6 ± 2.8 对 10.0 ± 3.9 ng/mL/h)。与诱导组相比,入院组的 PRA 在手术后 2 小时仍然较高(p = .01)。美洛昔康的血清 TxB2 低于罗苯昔布(p = .001),在导管置入时,美洛昔康的血清 TxB2 低于罗苯昔布各组。入院组(16/24 来自 RA 组和 MA 组)比其他组更早接受镇痛抢救(p = .033)。总之,尽管环氧化酶受到抑制,但麻醉期间肾素-血管紧张素系统仍被激活,这可能是由于低血压或手术刺激所致。药物或时间对肾功能指标没有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial

We evaluated the effect of administration timing of meloxicam and robenacoxib on renal function, platelet cyclo-oxygenase and perioperative analgesia in 60 cats undergoing ovariohysterectomy, in a prospective randomized blinded controlled study. Twelve cats were randomly allocated to one subcutaneous treatment group: meloxicam (0.2 mg/kg) or robenacoxib (2 mg/kg) at admission (MA, RA), at induction (MI, RI) and robenacoxib at the end of surgery (RE). All cats received the same anaesthesia protocol. Plasma renin activity (PRA), plasma creatinine, drug concentrations and serum thromboxane (TxB2) were measured sequentially. Anaesthesia significantly increased PRA, as activity at end of the surgery was higher than 2 h later (mean ± SD: 26.6 ± 2.8 versus 10.0 ± 3.9 ng/mL/h). PRA remained higher at 2 h post-surgery in admission groups compared to induction groups (p = .01). Serum TxB2 was lower with meloxicam than robenacoxib (p = .001), and was lower in the MA than each robenacoxib group at catheter placement. Admission groups (16/24 from RA and MA groups) received earlier rescue analgesia than other groups (p = .033). In conclusion, the renin-angiotensin system was activated during anaesthesia despite cyclo-oxygenase inhibition, possibly due to hypotension or surgical stimulation. There was no effect of drug or timing on the markers of renal function but one cat receiving meloxicam at induction had suspected IRIS grade II acute kidney injury.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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