多发性骨髓瘤的免疫功能健全小鼠模型:治疗意义

IF 2.5 3区 医学 Q2 HEMATOLOGY Hematology-Oncology Clinics of North America Pub Date : 2024-01-16 DOI:10.1016/j.hoc.2023.12.014
Megan Tien Du MS, Peter Leif Bergsagel MD, Marta Chesi PhD
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引用次数: 0

摘要

多发性骨髓瘤(MM)免疫功能健全的小鼠模型在T细胞重定向疗法时代尤为需要,以了解敏感性和耐药性的驱动因素、优化反应并防止毒性。有三种小鼠模型已被广泛鉴定:Balb/c 浆细胞瘤、5TMM 和 Vk*MYC。去年,又有新的小鼠模型诞生,它们首次捕捉到了原发性 MM 启动事件,如 MMSET/NSD2 或细胞周期蛋白 D1 失调。然而,肿瘤发生所需的潜伏期较长以及缺乏可移植品系限制了这些模型的使用。未来的研究应侧重于超二倍体 MM 的建模。
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Immunocompetent Mouse Models of Multiple Myeloma
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.
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