在微量元素结构改变的框架内,父母肥胖容易加剧儿童肥胖症的代谢和炎症紊乱。

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Nutrition & Diabetes Pub Date : 2024-01-18 DOI:10.1038/s41387-024-00258-6
Álvaro González-Domínguez, Lucía Jurado-Sumariva, Jesús Domínguez-Riscart, Ana Saez-Benito, Raúl González-Domínguez
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引用次数: 0

摘要

背景:众所周知,肥胖症家族史会增加后代患儿童肥胖症的几率,但其对潜在分子并发症的影响仍未得到研究。研究对象/方法:在此,我们调查了一个基于人群的队列,其中包括父母肥胖和父母不肥胖的肥胖儿童(PO+,20 人;PO-,29 人),以及作为对照的健康瘦弱儿童(30 人),并收集了他们的血浆和红细胞样本,以描述他们的多元素特征、炎症状态以及碳水化合物和脂质代谢:结果:我们发现,父母肥胖与儿童更不健康的结果有关,这反映在血胰岛素水平升高、胰岛素敏感性降低、血脂状况不佳以及促炎症环境等方面。与此同时,微量元素的含量也发生了适度变化,包括铜锌比值升高、血液循环中铁缺乏以及红细胞内金属积聚:因此,我们推测肥胖症家族史可能是影响儿童肥胖症背后多元素特征性改变的重要风险因素,进而可能导致与肥胖症相关的并发症和代谢并发症。
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Parental obesity predisposes to exacerbated metabolic and inflammatory disturbances in childhood obesity within the framework of an altered profile of trace elements.

Background: Family history of obesity is known to increase the odds of developing childhood obesity in the offspring, but its influence in underlying molecular complications remains unexplored.

Subjects/methods: Here, we investigated a population-based cohort comprising children with obesity, with and without parental obesity (PO+, N = 20; PO-, N = 29), and lean healthy children as controls (N = 30), from whom plasma and erythrocyte samples were collected to characterize their multi-elemental profile, inflammatory status, as well as carbohydrate and lipid metabolisms.

Results: We found parental obesity to be associated with unhealthier outcomes in children, as reflected in increased blood insulin levels and reduced insulin sensitivity, unfavorable lipid profile, and pro-inflammatory milieu. This was accompanied by moderate alterations in the content of trace elements, including increased copper-to-zinc ratios and iron deficiency in circulation, as well as metal accumulation within erythrocytes.

Conclusions: Therefore, we hypothesize that family history of obesity could be an important risk factor in modulating the characteristic multi-elemental alterations behind childhood obesity, which in turn could predispose to boost related comorbidities and metabolic complications.

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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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