{"title":"瞄准 \"组蛋白标记\"：癌症端粒动态表观遗传学调控的先进方法。","authors":"Ankita Das , Ashok K. Giri , Pritha Bhattacharjee","doi":"10.1016/j.bbagrm.2024.195007","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Telomere integrity is required for the maintenance of </span>genome stability<span> and prevention of oncogenic transformation of cells. Recent evidence suggests the presence of epigenetic modifications<span> as an important regulator of mammalian telomeres. Telomeric and subtelomeric regions are rich in epigenetic marks that regulate </span></span></span>telomere length<span><span> majorly through DNA methylation and post-translational histone modifications. Specific </span>histone modifying enzymes<span><span> play an integral role in establishing telomeric histone codes<span> necessary for the maintenance of structural integrity. Alterations of crucial histone moieties and histone modifiers cause deregulations in the telomeric chromatin leading to carcinogenic manifestations. This review delves into the significance of histone modifications and their influence on telomere dynamics concerning cancer. Additionally, it highlights the existing research gaps that hold the potential to drive the development of therapeutic interventions targeting the telomere </span></span>epigenome.</span></span></p></div>","PeriodicalId":55382,"journal":{"name":"Biochimica et Biophysica Acta-Gene Regulatory Mechanisms","volume":"1867 1","pages":"Article 195007"},"PeriodicalIF":2.6000,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeting ‘histone mark’: Advanced approaches in epigenetic regulation of telomere dynamics in cancer\",\"authors\":\"Ankita Das , Ashok K. Giri , Pritha Bhattacharjee\",\"doi\":\"10.1016/j.bbagrm.2024.195007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Telomere integrity is required for the maintenance of </span>genome stability<span> and prevention of oncogenic transformation of cells. Recent evidence suggests the presence of epigenetic modifications<span> as an important regulator of mammalian telomeres. Telomeric and subtelomeric regions are rich in epigenetic marks that regulate </span></span></span>telomere length<span><span> majorly through DNA methylation and post-translational histone modifications. Specific </span>histone modifying enzymes<span><span> play an integral role in establishing telomeric histone codes<span> necessary for the maintenance of structural integrity. Alterations of crucial histone moieties and histone modifiers cause deregulations in the telomeric chromatin leading to carcinogenic manifestations. This review delves into the significance of histone modifications and their influence on telomere dynamics concerning cancer. Additionally, it highlights the existing research gaps that hold the potential to drive the development of therapeutic interventions targeting the telomere </span></span>epigenome.</span></span></p></div>\",\"PeriodicalId\":55382,\"journal\":{\"name\":\"Biochimica et Biophysica Acta-Gene Regulatory Mechanisms\",\"volume\":\"1867 1\",\"pages\":\"Article 195007\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-01-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta-Gene Regulatory Mechanisms\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874939924000038\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta-Gene Regulatory Mechanisms","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874939924000038","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Targeting ‘histone mark’: Advanced approaches in epigenetic regulation of telomere dynamics in cancer
Telomere integrity is required for the maintenance of genome stability and prevention of oncogenic transformation of cells. Recent evidence suggests the presence of epigenetic modifications as an important regulator of mammalian telomeres. Telomeric and subtelomeric regions are rich in epigenetic marks that regulate telomere length majorly through DNA methylation and post-translational histone modifications. Specific histone modifying enzymes play an integral role in establishing telomeric histone codes necessary for the maintenance of structural integrity. Alterations of crucial histone moieties and histone modifiers cause deregulations in the telomeric chromatin leading to carcinogenic manifestations. This review delves into the significance of histone modifications and their influence on telomere dynamics concerning cancer. Additionally, it highlights the existing research gaps that hold the potential to drive the development of therapeutic interventions targeting the telomere epigenome.
期刊介绍：
BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.
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