Shakiba Hassanzadeh, Linlin Gao, Anthony M Alvarado, Paul J Camarata, Nelli S Lakis, Mohammad Haeri
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The pathogenesis of CA and the involvement of other factors (genetics or environmental factors) are still unknown and require further investigation. We are presenting a young man who presented for evaluation of seizure-like events without any family history of neurologic conditions. The physical examination was unremarkable except for a slightly antalgic gait. Imaging studies showed an extra-axial left tentorial mass suggestive of a meningioma, hemangiopericytoma, or other extra-axial lesions. The lesion was resected where its vascular nature was mentioned initially, and the histology proved the diagnosis of cavernous angioma. Here we give an overview of the known pathogenesis, causes, clinical features, and diagnostic and therapeutic options in CA. 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引用次数: 0
摘要
海绵状血管瘤(CA)是一种良性血管畸形,主要出现在脑实质内,因此被称为轴内海绵状血管瘤。而轴外硬脑膜海绵状血管瘤则是在脑实质外发现的罕见血管病变。它们发生在中窝,由于位于轴外,很容易被误诊为脑膜瘤。此外,位于中窝外(如凸部)的 CA 预后较好,因为它们更容易进行手术。手术切除是治疗 CA 的主要选择。不过,栓塞和放射治疗等其他方法也可作为治疗选择或辅助治疗选择。CA的发病机制和其他因素(遗传或环境因素)的参与尚不清楚,需要进一步研究。我们在此介绍一名因癫痫发作样事件前来就诊的年轻男子,他没有任何神经系统疾病的家族史。体格检查除步态略有蹒跚外,其他均无异常。影像学检查显示,他的左侧蝶骨轴外肿块提示脑膜瘤、血管瘤或其他轴外病变。病变切除后,组织学检查证实了海绵状血管瘤的诊断。在此,我们将概述 CA 的已知发病机制、病因、临床特征以及诊断和治疗方案。更好地了解海绵状血管瘤、其病因、临床特征和治疗方案将有助于临床医生进行早期诊断和患者管理。
Extra-Axial Cavernous Angioma: A Case Report and Review of the Literature.
Cavernous angiomas (CAs) are benign vascular malformations predominantly seen in the brain parenchyma and therefore referred to as intra-axial. Extra-axial dural-based cavernous angiomas, on the other hand, are rare vascular lesions found outside of the brain parenchyma. They occur in the middle fossa and may be easily misdiagnosed as meningiomas due to their extra-axial location. In addition, CAs that are located outside the middle fossa, such as in the convexity, have a better prognosis since they are more surgically accessible. Surgical resection is the main treatment of choice in CAs. However, other options, such as embolization and radiotherapy, may also be considered therapeutic choices or additive treatment options. The pathogenesis of CA and the involvement of other factors (genetics or environmental factors) are still unknown and require further investigation. We are presenting a young man who presented for evaluation of seizure-like events without any family history of neurologic conditions. The physical examination was unremarkable except for a slightly antalgic gait. Imaging studies showed an extra-axial left tentorial mass suggestive of a meningioma, hemangiopericytoma, or other extra-axial lesions. The lesion was resected where its vascular nature was mentioned initially, and the histology proved the diagnosis of cavernous angioma. Here we give an overview of the known pathogenesis, causes, clinical features, and diagnostic and therapeutic options in CA. Better knowledge about CA, its causes, clinical features, and treatment options would help clinicians in early diagnosis and patient management.