干细胞研究中的单细胞技术。

Ali Golchin, Forough Shams, Faezeh Moradi, Amin Ebrahimi Sadrabadi, Shima Parviz, Shahriar Alipour, Parviz Ranjbarvan, Yaser Hemmati, Maryam Rahnama, Yousef Rasmi, Shiva Gholizadeh-Ghaleh Aziz
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摘要

单细胞技术(Single-cell technology,SCT)可对生物器官、组织和细胞的基本单位进行检测,已成为一种强大的工具,尤其是在生物学领域,对干细胞研究产生了深远的影响。这项创新技术为获取细胞特异性数据和深入了解支配器官功能和生物学的分子途径开辟了新途径。SCT 不仅常用于探索包括干细胞在内的稀有和多样化细胞类型,还能揭示细胞多样性和动态的复杂性。这一视角对推进干细胞研究至关重要,它有助于对分子动态和细胞功能随时间变化进行非侵入性分析。尽管对干细胞治疗遗传性疾病、退行性病症和严重损伤的潜在方法进行了大量研究,但获得批准的干细胞治疗方法仍然有限。造成这种限制的原因是干细胞来源存在各种异质性,阻碍了干细胞在临床上的广泛应用。此外,干细胞研究与微流体器官组织、CRISPR技术和细胞/组织工程等尖端技术密切相关。为克服干细胞研究限制而开发的每一种策略,都有可能对先进的干细胞疗法产生重大影响。本研究借鉴基于SCT方法的优势和取得的进展,旨在概述在干细胞研究及其相关领域利用SCT的相关进展和概念。
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Single-cell Technology in Stem Cell Research.

Single-cell technology (SCT), which enables the examination of the fundamental units comprising biological organs, tissues, and cells, has emerged as a powerful tool, particularly in the field of biology, with a profound impact on stem cell research. This innovative technology opens new pathways for acquiring cell-specific data and gaining insights into the molecular pathways governing organ function and biology. SCT is not only frequently used to explore rare and diverse cell types, including stem cells, but it also unveils the intricacies of cellular diversity and dynamics. This perspective, crucial for advancing stem cell research, facilitates non-invasive analyses of molecular dynamics and cellular functions over time. Despite numerous investigations into potential stem cell therapies for genetic disorders, degenerative conditions, and severe injuries, the number of approved stem cell-based treatments remains limited. This limitation is attributed to the various heterogeneities present among stem cell sources, hindering their widespread clinical utilization. Furthermore, stem cell research is intimately connected with cutting-edge technologies, such as microfluidic organoids, CRISPR technology, and cell/tissue engineering. Each strategy developed to overcome the constraints of stem cell research has the potential to significantly impact advanced stem cell therapies. Drawing from the advantages and progress achieved through SCT-based approaches, this study aims to provide an overview of the advancements and concepts associated with the utilization of SCT in stem cell research and its related fields.

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