{"title":"关于 \"一种线粒体定位的双光子光敏剂产生碳自由基对抗缺氧肿瘤 \"的通讯。","authors":"Hans-Gert Korth","doi":"10.1002/anie.202300176","DOIUrl":null,"url":null,"abstract":"<p><p>It is shown that data presented in a paper by Chao and co-workers do not support the formation of active \"Carbon Radicals\" as claimed according to the title. The assignments of observed ESR spectra and the mechanistic interpretation are severely flawed. Hence, other reactive intermediates must be responsible for the observed tumor-damaging effects.</p>","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":null,"pages":null},"PeriodicalIF":16.1000,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correspondence on \\\"A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals Against Hypoxic Tumors\\\".\",\"authors\":\"Hans-Gert Korth\",\"doi\":\"10.1002/anie.202300176\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>It is shown that data presented in a paper by Chao and co-workers do not support the formation of active \\\"Carbon Radicals\\\" as claimed according to the title. The assignments of observed ESR spectra and the mechanistic interpretation are severely flawed. Hence, other reactive intermediates must be responsible for the observed tumor-damaging effects.</p>\",\"PeriodicalId\":125,\"journal\":{\"name\":\"Angewandte Chemie International Edition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.1000,\"publicationDate\":\"2024-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Angewandte Chemie International Edition\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1002/anie.202300176\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angewandte Chemie International Edition","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/anie.202300176","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Correspondence on "A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals Against Hypoxic Tumors".
It is shown that data presented in a paper by Chao and co-workers do not support the formation of active "Carbon Radicals" as claimed according to the title. The assignments of observed ESR spectra and the mechanistic interpretation are severely flawed. Hence, other reactive intermediates must be responsible for the observed tumor-damaging effects.
期刊介绍:
Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.