紧密连接蛋白与胆道疾病。

IF 2.6 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Current Opinion in Gastroenterology Pub Date : 2024-03-01 Epub Date: 2024-01-19 DOI:10.1097/MOG.0000000000000996
Grégory Merlen, Thierry Tordjmann
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引用次数: 0

摘要

综述的目的:在胆管病变和更广泛的肝病的病理生理学背景下,虽然从概念上讲,维持胆管细胞间和肝细胞间紧密连接的完整性对于保护肝脏至关重要,但专门针对这一主题的研究却很少。事实上,在肝脏中,改变紧密连接、控制细胞旁通透性的细胞间粘附复合物会导致胆管和胆管渗漏,使胆汁逆流至肝实质,在疾病过程中造成损伤:近几十年来,有关紧密连接结构组织和紧密连接相关信号通路的信息大量涌现,为胆道疾病发病过程中调节细胞旁通透性的潜在干预措施提供了线索。有趣的是,有报道称几种肝病与一种或几种紧密连接蛋白的异常表达有关。摘要:在这篇综述中,我们概述了在各种胆道疾病中描述的紧密连接紊乱,这将为确定该领域的新治疗靶点铺平道路。
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Tight junction proteins and biliary diseases.

Purpose of review: In the pathophysiological context of cholangiopathies and more broadly of hepatopathies, while it is conceptually clear that the maintenance of inter-cholangiocyte and inter-hepatocyte tight junction integrity would be crucial for liver protection, only scarce studies have been devoted to this topic. Indeed, in the liver, alteration of tight junctions, the intercellular adhesion complexes that control paracellular permeability would result in leaky bile ducts and bile canaliculi, allowing bile reflux towards hepatic parenchyma, contributing to injury during the disease process.

Recent findings: Last decades have provided a great deal of information regarding both tight junction structural organization and signaling pathways related to tight junctions, providing clues about potential intervention to modulate paracellular permeability during cholangiopathies pathogenesis. Interestingly, several liver diseases have been reported to be associated with abnormal expression of one or several tight junction proteins. However, the question remains unanswered if these alterations would be primarily involved in the disease pathogenesis or if they would occur secondarily in the pathological course.

Summary: In this review, we provide an overview of tight junction disruptions described in various biliary diseases that should pave the way for defining new therapeutic targets in this field.

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来源期刊
Current Opinion in Gastroenterology
Current Opinion in Gastroenterology 医学-胃肠肝病学
CiteScore
5.30
自引率
0.00%
发文量
137
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in Gastroenterology features hand-picked review articles from our team of expert editors. With twelve disciplines published across the year – including gastrointestinal infections, nutrition and inflammatory bowel disease – every issue also contains annotated references detailing the merits of the most important papers.
期刊最新文献
Updates on therapeutic endoscopic ultrasound. Tight junction regulation, intestinal permeability, and mucosal immunity in gastrointestinal health and disease. Endoscopic therapies for bariatric surgery complications. Gastroduodenal injury and repair mechanisms. Nutritional aspects in patients with gastroparesis.
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