Quang Hao Nguyen, M. Vu, Tuan Anh Tran, Quoc Chinh Duong, Duc Binh Vu, Ha Thanh Nguyen, Quoc Khanh Bach
{"title":"分子国际预后评分系统(IPSS-M)与修订版国际预后评分系统(IPSS-R)在预测接受地西他滨治疗的骨髓增生异常肿瘤患者预后方面的比较","authors":"Quang Hao Nguyen, M. Vu, Tuan Anh Tran, Quoc Chinh Duong, Duc Binh Vu, Ha Thanh Nguyen, Quoc Khanh Bach","doi":"10.1515/oncologie-2023-0406","DOIUrl":null,"url":null,"abstract":"Abstract Background Molecular International Prognostic Scoring System (IPSS-M) is a newly developed prognostic model for myelodysplastic neoplasms (MDS), but has not yet been used widely. In this study, we aimed to compare the IPSS-M with the traditional Revised International Prognostic Scoring System (IPSS-R) in predicting the prognosis of decitabine treated-MDS patients. Patients and methods This retrospective cohort study was conducted on 19 newly diagnosed MDS patients who were examined for 51 gene mutations and received decitabine treatment. The survival analysis, including overall survival (OS), progression-free survival (PFS), and leukemia-free survival (LFS), was performed using the Kaplan–Meier method. Comparisons between the risk groups were carried out according to the IPSS-R and IPSS-M models. Results Among the 19 MDS patients, 12 (63.2 %) showed myeloid gene mutations, with the highest frequency of mutations in ASXL1, RUNX1, SRSF2, TET2, and TP53 (15.8 %). Survival analysis found that the OS was significantly different between the risk groups of both IPSS-R and IPSS-M models, but the PFS and LFS showed significant differences between the risk groups in only the IPSS-M model. The PFS of the moderate, high, and very high-risk groups were 34.66, 25.00, and 15.33 months (p=0.031); respectively. The LFS of the moderate, high, and very high-risk groups were 39.20, 25.00, and 18.37 months, (p=0.039); respectively. Conclusions Our results found that IPSS-M was better than IPSS-R in predicting the PFS and LFS of decitabine-treated MDS patients, IPSS-M may be superior to IPSS-R in predicting the prognosis of MDS patients.","PeriodicalId":54687,"journal":{"name":"Oncologie","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of the Molecular International Prognostic Scoring System (IPSS-M) and Revised International Prognostic Scoring System (IPSS-R) in predicting the prognosis of patients with myelodysplastic neoplasms treated with decitabine\",\"authors\":\"Quang Hao Nguyen, M. Vu, Tuan Anh Tran, Quoc Chinh Duong, Duc Binh Vu, Ha Thanh Nguyen, Quoc Khanh Bach\",\"doi\":\"10.1515/oncologie-2023-0406\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Background Molecular International Prognostic Scoring System (IPSS-M) is a newly developed prognostic model for myelodysplastic neoplasms (MDS), but has not yet been used widely. In this study, we aimed to compare the IPSS-M with the traditional Revised International Prognostic Scoring System (IPSS-R) in predicting the prognosis of decitabine treated-MDS patients. Patients and methods This retrospective cohort study was conducted on 19 newly diagnosed MDS patients who were examined for 51 gene mutations and received decitabine treatment. The survival analysis, including overall survival (OS), progression-free survival (PFS), and leukemia-free survival (LFS), was performed using the Kaplan–Meier method. Comparisons between the risk groups were carried out according to the IPSS-R and IPSS-M models. Results Among the 19 MDS patients, 12 (63.2 %) showed myeloid gene mutations, with the highest frequency of mutations in ASXL1, RUNX1, SRSF2, TET2, and TP53 (15.8 %). Survival analysis found that the OS was significantly different between the risk groups of both IPSS-R and IPSS-M models, but the PFS and LFS showed significant differences between the risk groups in only the IPSS-M model. The PFS of the moderate, high, and very high-risk groups were 34.66, 25.00, and 15.33 months (p=0.031); respectively. The LFS of the moderate, high, and very high-risk groups were 39.20, 25.00, and 18.37 months, (p=0.039); respectively. Conclusions Our results found that IPSS-M was better than IPSS-R in predicting the PFS and LFS of decitabine-treated MDS patients, IPSS-M may be superior to IPSS-R in predicting the prognosis of MDS patients.\",\"PeriodicalId\":54687,\"journal\":{\"name\":\"Oncologie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-01-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oncologie\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1515/oncologie-2023-0406\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncologie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/oncologie-2023-0406","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Comparison of the Molecular International Prognostic Scoring System (IPSS-M) and Revised International Prognostic Scoring System (IPSS-R) in predicting the prognosis of patients with myelodysplastic neoplasms treated with decitabine
Abstract Background Molecular International Prognostic Scoring System (IPSS-M) is a newly developed prognostic model for myelodysplastic neoplasms (MDS), but has not yet been used widely. In this study, we aimed to compare the IPSS-M with the traditional Revised International Prognostic Scoring System (IPSS-R) in predicting the prognosis of decitabine treated-MDS patients. Patients and methods This retrospective cohort study was conducted on 19 newly diagnosed MDS patients who were examined for 51 gene mutations and received decitabine treatment. The survival analysis, including overall survival (OS), progression-free survival (PFS), and leukemia-free survival (LFS), was performed using the Kaplan–Meier method. Comparisons between the risk groups were carried out according to the IPSS-R and IPSS-M models. Results Among the 19 MDS patients, 12 (63.2 %) showed myeloid gene mutations, with the highest frequency of mutations in ASXL1, RUNX1, SRSF2, TET2, and TP53 (15.8 %). Survival analysis found that the OS was significantly different between the risk groups of both IPSS-R and IPSS-M models, but the PFS and LFS showed significant differences between the risk groups in only the IPSS-M model. The PFS of the moderate, high, and very high-risk groups were 34.66, 25.00, and 15.33 months (p=0.031); respectively. The LFS of the moderate, high, and very high-risk groups were 39.20, 25.00, and 18.37 months, (p=0.039); respectively. Conclusions Our results found that IPSS-M was better than IPSS-R in predicting the PFS and LFS of decitabine-treated MDS patients, IPSS-M may be superior to IPSS-R in predicting the prognosis of MDS patients.
期刊介绍:
Oncologie is aimed to the publication of high quality original research articles, review papers, case report, etc. with an active interest in vivo or vitro study of cancer biology. Study relating to the pathology, diagnosis, and advanced treatment of all types of cancers, as well as research from any of the disciplines related to this field of interest. The journal has English and French bilingual publication.