{"title":"双胞胎研究：影响正常范围内游离甲状腺素水平的基因型依赖性表观遗传因素。","authors":"Saki Yoshioka, Yuya Arakawa, Mika Hasegawa, Shiho Kato, Hinako Hashimoto, Saho Mori, Hiromichi Ueda, Mikio Watanabe","doi":"10.2217/epi-2023-0372","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To explore the clinical application of DNA methylation affecting thyroid function, we evaluated the association of DNA methylation with free thyroxine (FT4) and TSH measurements in monozygotic twins. <b>Materials & methods:</b> Discordant pairs for FT4 or TSH levels were examined for the relationship between the within-pair difference of each measurement and the DNA methylation levels using epigenome-wide association studies. The contribution of polymorphisms to the methylation sensitivity was also examined. <b>Results:</b> We found two CpG sites significantly associated with FT4 levels, and also some CpG sites showing significant differences in their methylation levels within FT4-discordant pairs depending on the polymorphism in <i>EPHB2</i>. <b>Conclusion:</b> The FT4 level may be associated with a combination of methylation and polymorphisms in the <i>EPHB2</i> gene.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"147-158"},"PeriodicalIF":2.6000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range.\",\"authors\":\"Saki Yoshioka, Yuya Arakawa, Mika Hasegawa, Shiho Kato, Hinako Hashimoto, Saho Mori, Hiromichi Ueda, Mikio Watanabe\",\"doi\":\"10.2217/epi-2023-0372\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> To explore the clinical application of DNA methylation affecting thyroid function, we evaluated the association of DNA methylation with free thyroxine (FT4) and TSH measurements in monozygotic twins. <b>Materials & methods:</b> Discordant pairs for FT4 or TSH levels were examined for the relationship between the within-pair difference of each measurement and the DNA methylation levels using epigenome-wide association studies. The contribution of polymorphisms to the methylation sensitivity was also examined. <b>Results:</b> We found two CpG sites significantly associated with FT4 levels, and also some CpG sites showing significant differences in their methylation levels within FT4-discordant pairs depending on the polymorphism in <i>EPHB2</i>. <b>Conclusion:</b> The FT4 level may be associated with a combination of methylation and polymorphisms in the <i>EPHB2</i> gene.</p>\",\"PeriodicalId\":11959,\"journal\":{\"name\":\"Epigenomics\",\"volume\":\" \",\"pages\":\"147-158\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epigenomics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2217/epi-2023-0372\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epigenomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2217/epi-2023-0372","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
摘要
目的：为了探索影响甲状腺功能的 DNA 甲基化的临床应用，我们评估了 DNA 甲基化与单卵双生子游离甲状腺素（FT4）和促甲状腺激素（TSH）测量值的相关性。材料与方法利用全表观基因组关联研究，对FT4或TSH水平不一致的双生子对内差异与DNA甲基化水平之间的关系进行了研究。同时还研究了多态性对甲基化敏感性的贡献。结果发现我们发现两个 CpG 位点与 FT4 水平显著相关，而且根据 EPHB2 的多态性，一些 CpG 位点在 FT4 不一致的配对中显示出显著的甲基化水平差异。结论FT4 水平可能与 EPHB2 基因的甲基化和多态性共同作用有关。
Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range.
Aim: To explore the clinical application of DNA methylation affecting thyroid function, we evaluated the association of DNA methylation with free thyroxine (FT4) and TSH measurements in monozygotic twins. Materials & methods: Discordant pairs for FT4 or TSH levels were examined for the relationship between the within-pair difference of each measurement and the DNA methylation levels using epigenome-wide association studies. The contribution of polymorphisms to the methylation sensitivity was also examined. Results: We found two CpG sites significantly associated with FT4 levels, and also some CpG sites showing significant differences in their methylation levels within FT4-discordant pairs depending on the polymorphism in EPHB2. Conclusion: The FT4 level may be associated with a combination of methylation and polymorphisms in the EPHB2 gene.
期刊介绍：
Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community.
Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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