分子尸检在年轻人心脏性猝死中的作用。

IF 41.7 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Nature Reviews Cardiology Pub Date : 2024-01-23 DOI:10.1038/s41569-024-00989-0

Julia C. Isbister, Christopher Semsarian

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引用次数: 0

摘要

分子尸检适用于常规尸检未找到明确病因的心脏性猝死病例，目的是找出可能导致死亡的病理基因变异。随着人们对遗传性心肌病在无结构性改变的情况下发生恶性心律失常的认识不断提高，分子尸检的适用性也随之增强，家属的护理也得到了改善，但临床医生也面临着新的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of the molecular autopsy in sudden cardiac death in young individuals

A molecular autopsy is undertaken in cases of sudden cardiac death with no definitive cause found after conventional autopsy, with the aim of identifying a pathological genetic variant that could account for the death. Greater awareness of malignant arrhythmias in the absence of structural changes in inherited cardiomyopathies has increased the applicability of molecular autopsies, and resulted in improved care of families but new challenges for clinicians.

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.