妊娠相关黑色素瘤:2002 年至 2020 年的特征和结果。

IF 1.5 4区 医学 Q3 DERMATOLOGY Melanoma Research Pub Date : 2024-04-01 Epub Date: 2024-01-23 DOI:10.1097/CMR.0000000000000953
Tara M Davidson, Tina J Hieken, Amy E Glasgow, Elizabeth B Habermann, Yiyi Yan
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引用次数: 0

摘要

怀孕 1 年内确诊的黑色素瘤被定义为妊娠相关黑色素瘤(PAM)。目前还没有关于妊娠如何影响黑色素瘤的可靠数据,也没有治疗妊娠相关黑色素瘤的指南。经 IRB 批准,我们对 2000 年至 2020 年期间在本机构接受治疗并经病理确诊为妊娠期 1 年内黑色素瘤的女性患者进行了鉴定。与癌症登记处的对照组进行了 1 :如果有年龄、手术年份(±5)和分期的对照,则按 1 : 4 进行配对。我们确定了 83 名 PAM 患者,中位随访时间为 86 个月。确诊时的平均年龄为 31 岁。80%为AJCC V8 I期,2.4%为II期,13%为III期,4.8%为IV期。平均布氏厚度为 0.79 毫米,3.6% 出现溃疡。平均有丝分裂率为 0.76/mm2。在 PAM 管理方面,98.6% 的 ESD 患者和 86.7% 的 LSD 患者根据其疾病分期接受了 NCCN 指南规定的标准治疗。临床上未发现明显的治疗延误。LSD 患者从诊断到接受系统治疗的时间平均为 46 天(95% CI:34-59 天)。将 83 例 PAM 患者与 309 例年龄、分期和诊断年份相匹配的对照组进行比较,观察到相似的 5 年总生存率(97% vs. 97%,P = 0.95)或无复发生存率(96% vs. 96%,P = 0.86)。在高度专业化的黑色素瘤治疗中心接受 SOC 治疗后,根据临床病理特征进行匹配后,PAM 的疗效与非 PAM 相当。我们鼓励为患有 PAM 的女性提供专科中心治疗。
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Pregnancy-associated melanoma: characteristics and outcomes from 2002 to 2020.

Melanoma diagnosed within 1 year of pregnancy is defined as pregnancy-associated melanoma (PAM). No robust data on how pregnancy influences melanoma nor guidelines for PAM management exist. With IRB approval, female patients with a pathology-confirmed melanoma diagnosis within 1 year of pregnancy treated at our institution from 2000 to 2020 were identified. Controls from the cancer registry were matched 1 : 4 when available on decade of age, year of surgery (±5), and stage. We identified 83 PAM patients with median follow-up of 86 months. Mean age at diagnosis was 31 years. 80% AJCC V8 stage I, 2.4% stage II, 13% stage III, 4.8% stage IV. Mean Breslow thickness was 0.79 mm and 3.6% exhibited ulceration. The mean mitotic rate was 0.76/mm 2 . In terms of PAM management, 98.6% of ESD patients and 86.7% of LSD patients received standard-of-care therapy per NCCN guidelines for their disease stage. No clinically significant delays in treatment were noted. Time to treatment from diagnosis to systemic therapy for LSD patients was an average of 46 days (95% CI: 34-59 days). Comparing the 83 PAM patients to 309 controls matched on age, stage, and year of diagnosis, similar 5-year overall survival (97% vs. 97%, P  = 0.95) or recurrence-free survival (96% vs. 96%, P  = 0.86) was observed. The outcomes of PAM following SOC treatment at a highly specialized center for melanoma care were comparable to non-PAM when matched by clinical-pathologic features. Specialty center care is encouraged for women with PAM.

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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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